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Table 1 Correlations between CA9 expression and clinicopathological parameters in CNB of 102 primary breast cancers

From: Carbonic anhydrase 9 is associated with chemosensitivity and prognosis in breast cancer patients treated with taxane and anthracycline

   CA9 expression  
Parameter Positive Negative  
  (n = 47) (n = 55) p-value
Age    
≥55 21 (42%) 29 (58%)  
<55 26 (50%) 26 (50%) 0.418
Menopause    
Positive 31 (44%) 40 (56%)  
Negative 16 (52%) 15 (48%) 0.459
Intrinsic subtype    
Luminal 22 (48%) 24 (52%)  
Luminal-HER 4 (50%) 4 (50%)  
HER2 4 (24%) 13 (76%) 0.209
Triple-negative 17 (55%) 14 (45%)  
Tumor size    
≥ 4 cm 12 (67%) 6 (33%)  
< 4 cm 35 (42%) 49 (58%) 0.053
Lymph node status    
Positive 23 (70%) 10 (30%)  
Negative 24 (35%) 45 (65%) 0.001
Lymph-vascular invasion    
Positive 20 (69%) 9 (31%)  
Negative 27 (37%) 46 (63%) 0.003
Nuclear grade (NG)    
NG1 32 (43%) 42 (57%)  
NG 2&3 15 (54%) 13 (46%) 0.350
Pathological response    
pCR 7 (23%) 23 (77%)  
Non-pCR 40 (56%) 32 (44%) 0.003
Responder (histological grade 2&3) 16 (29%) 40 (71%)  
non-Responder (histological grade 1) 31 (67%) 15 (33%) <0.001
Clinical response    
Responder (cCR + cPR) 33 (41%) 47 (59%)  
non-Responder (cNC + cPD) 14 (64%) 8 (36%) 0.062
Recurrence    
Yes 22 (79%) 6 (21%)  
No 25 (34%) 49 (66%) <0.001