Figure 4

MME expression is associated with poor prognosis in lung adenocarcinoma patients treated with surgery. (A) Based on the expression of MME in microarrays from tumor specimens, NSCLC patients from publically available GEO microarray series were stratified into patients with high MME expression (the highest quartile) versus low MME expression (the remaining three quartiles). The association between MME expression and overall survival was calculated within the GEO series, and in cohorts derived by combining the different GEO series. All analyses were performed in a multivariate manner with pathological tumor stage as stratification variable. Adenocarcinoma and non-adenocarcinoma patients from each study were analyzed separately. Study GSE13213 contained only adenocarcinoma patients. From study GSE11969 only the non-adenocarcinoma patients were included due to potential overlap with patients from GSE13213, who were operated at the same centre. Results are displayed as hazard ratio for death in the high MME group versus the low MME group +/- 95% confidence interval. (B) Kaplan-Meier plot of overall survival in adenocarcinoma patients (n = 182) and non-adenocarcinoma patients (n = 160) from the combined cohort dichotomized according to the expression levels of MME.