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Table 2 ERα/ERβ1 expression patterns in female PTC patients of reproductive age and of advanced reproductive age a

From: Differential expression patterns and clinical significance of estrogen receptor-α and β in papillary thyroid carcinoma

 

Reproductive age (n = 50)

Advanced reproductive age (n = 39)

P-value

ERα

Positive percentage

30/50 (60.0%)

18/39 (46.2%)

0.194

Total score b

3.44 ± 2.80

2.92 ± 3.35

0.342

Subcellular localization

Nu

22/30 (73.3%)

7/18 (38.9%)

0.011

Nu + Cyto

6/30 (20.0%)

3/18 (16.7%)

Cyto

2/30 (6.7%)

8/18 (44.4%)

ERβ1

Positive percentage

48/50 (96.0%)

39/39 (100%)

0.206

Total score

6.36 ± 1.64

6.69 ± 1.10

0.391

Subcellular localization

Nu

7/48 (14.6%)

3/39 (7.7%)

0.404

Nu + Cyto

36/48 (75.0%)

30/39 (76.9%)

Cyto

5/48 (10.4%)

6/39 (15.4%)

  1. aThe female patients of reproductive age were 18–45 years old, while those of advanced reproductive age were all above 45 years old. bTotal score was calculated from the sum of proportion staining score and intensity score to reflect the expression level, which is given as mean ± standard deviation (S.D.). PTC, papillary thyroid cancer; Nu, exclusively nuclear staining; Nu + Cyto, combined nuclear and cytoplasmic staining; Cyto, exclusively cytoplasmic staining.