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Table 2 Gender-specific incidence density rates and SIRs for cancer sites

From: Cancer risks among patients with type 2 diabetes: a 10-year follow-up study of a nationwide population-based cohort in Taiwan

  General population(a) Population with type2 diabetes Main analysis using outpatient and inpatient databases After excluding cancer cases diagnosed within 1 year of entry(b) Using Registry for Catastrophic Illness Database(c)
Type of cancer O Incidence density# O Incidence density# SIR 95% CI SIR 95% CI SIR 95% CI
Men           
  Lung 53072 1.14 7493 3.64 0.99 (0.97-1.02) 0.96 (0.94-0.99)** 0.74 (0.72-0.77)***
  Liver 64321 1.39 9375 4.57 1.61 (1.57-1.64)*** 1.59 (1.55-1.62)*** 1.70 (1.65-1.76)***
  Colorectal 46715 1.01 6048 2.92 1.19 (1.15-1.22)*** 1.16 (1.13-1.20)*** 1.12 (1.07-1.17)***
  Stomach 18918 0.41 2528 1.21 0.96 (0.92-1.00)* 0.96 (0.92-1.00) 0.89 (0.85-0.95)***
  Oral 30942 0.67 2411 1.15 1.16 (1.12-1.21)*** 1.15 (1.10-1.21)*** 1.09 (1.03-1.15)**
  Prostate 27767 0.60 4259 2.05 0.96 (0.93-0.99)* 0.94 (0.91-0.97)*** 0.89 (0.85-0.94)***
  Esophagus 11667 0.25 1073 0.51 0.88 (0.82-0.94)*** 0.88 (0.82-0.94)*** 0.69 (0.63-0.75)***
  Pancreas 7023 0.15 1337 0.64 1.62 (1.53-1.72)*** 1.56 (1.46-1.67)*** 1.60 (1.45-1.77)***
  Cervix - - - - - - - - - -
  Nasopharyngeal 20022 0.43 1251 0.60 1.09 (1.03-1.16)*** 1.04 (0.98-1.11) 0.85 (0.76-0.95)**
  Small intestine 2129 0.05 287 0.14 1.15 (1.02-1.31)* 1.11 (0.97-1.28) 0.82 (0.64-1.05)
  Gallbladder 4522 0.10 693 0.33 1.18 (1.08-1.28)*** 1.15 (1.05-1.25)** 1.10 (0.97-1.25)
  Retroperitoneum and peritoneum 1274 0.03 160 0.08 1.19 (1.00-1.40)* 1.14 (0.95-1.37) 1.06 (0.74-1.51)
  Larynx 6821 0.15 596 0.28 0.84 (0.77-0.91)*** 0.83 (0.79-0.91)*** 0.75 (0.65-0.85)***
  Respiratory and intrathoratic organs 7399 0.16 745 0.36 0.93 (0.86-1.00) 0.90 (0.83-0.98)* 0.81 (0.65-1.00)*
  Bone 3778 0.08 350 0.17 0.93 (0.83-1.04) 0.90 (0.79-1.01) 0.90 (0.64-1.26)
  Connective and other soft tissue 4536 0.10 428 0.20 1.07 (0.96-1.18) 1.06 (0.95-1.18) 0.81 (0.64-1.03)
  Skin 1605 0.03 199 0.09 1.10 (0.95-1.28) 1.08 (0.92-1.27) 1.10 (0.85-1.43)
  Testis 2017 0.04 127 0.06 1.16 (0.96-1.40) 1.18 (0.97-1.44) 0.71 (0.34-1.47)
  Penis 1132 0.02 148 0.07 1.88 (1.57-2.25)*** 1.41 (1.16-1.71)*** 1.32 (0.96-1.82)
  Bladder 12758 0.27 1802 0.86 1.07 (1.02-1.13)** 1.04 (0.99-1.10) 0.99 (0.92-1.06)
  Kidney 9913 0.21 1504 0.72 1.32 (1.25-1.40)*** 1.30 (1.22-1.38)*** 1.28 (1.17-1.40)***
  Brain 7596 0.16 732 0.35 1.03 (0.96-1.12) 0.99 (0.91-1.08) 0.77 (0.65-0.92)**
  Hodgkin’s disease 760 0.02 106 0.05 1.69 (1.37-2.10)*** 1.42 (1.11-1.81)** 1.05 (0.63-1.73)
  Leukemia 4917 0.11 928 0.44 1.86 (1.73-2.00)*** 1.66 (1.54-1.80)*** 0.96 (0.84-1.09)
  Carcinoma in situ 11323 0.24 1251 0.60 1.18 (1.11-1.25)*** 1.15 (1.07-1.23)*** 0.81 (0.18-3.58)
Women           
  Lung 24872 0.66 4498 2.11 0.98 (0.95-1.02) 0.97 (0.94-1.00) 0.74 (0.70-0.78)***
  Liver 28577 0.75 6061 2.85 1.55 (1.51-1.60)*** 1.54 (1.49-1.58)*** 1.67 (1.60-1.75)***
  Colorectal 33469 0.88 5502 2.59 1.16 (1.13-1.20)*** 1.15 (1.11-1.18)*** 1.07 (1.01-1.12)***
  Breast 42441 1.12 2934 1.37 1.14 (1.09-1.18)*** 1.13 (1.09-1.18)*** 1.09 (1.04-1.14)***
  Stomach 9632 0.25 1830 0.85 1.11 (1.05-1.17)*** 1.12 (1.06-1.18)*** 1.05 (0.98-1.13)
  Oral 4970 0.13 733 0.34 1.30 (1.20-1.42)*** 1.27 (1.16-1.39)*** 1.08 (0.94-1.25)
  Esophagus 7500 0.20 648 0.30 1.08 (0.99-1.18) 1.06 (0.97-1.16) 0.70 (0.54-0.90)**
  Pancreas 4700 0.12 1071 0.50 1.44 (1.34-1.55)*** 1.42 (1.32-1.53)*** 1.31 (1.17-1.46)***
  Cervix 27472 0.73 2579 1.21 0.94 (0.90-0.99)** 0.93 (0.89-0.98)** 0.84 (0.79-0.90)***
  Nasopharyngeal 8789 0.23 690 0.32 1.14 (1.05-1.24)** 1.09 (0.99-1.19) 0.98 (0.82-1.18)
  Small intestine 1248 0.03 222 0.10 1.11 (0.96-1.29) 1.04 (0.88-1.22) 1.04 (0.81-1.34)
  Gallbladder 3278 0.09 697 0.32 1.10 (1.01-1.20)* 1.08 (0.99-1.19) 1.08 (0.96-1.22)
  Retroperitoneum and peritoneum 1358 0.04 201 0.09 1.16 (0.99-1.35) 1.13 (0.95-1.33) 1.16 (0.89-1.52)
  Larynx 1272 0.03 137 0.06 1.30 (1.07-1.57)** 1.35 (1.10-1.66)** 1.41 (0.87-2.27)
  Respiratory and intrathoratic organs 3889 0.10 495 0.23 0.94 (0.85-1.04) 0.92 (0.83-1.02) 0.66 (0.50-0.88)**
  Bone 2555 0.07 333 0.15 1.03 (0.91-1.16) 1.00 (0.88-1.14) 0.78 (0.52-1.18)
  Connective and other soft tissue 3284 0.09 309 0.14 0.86 (0.76-0.97)* 0.84 (0.73-0.95)** 0.76 (0.58-0.99)*
  Skin 1265 0.03 189 0.09 1.10 (0.94-1.29) 0.99 (0.83-1.18) 0.93 (0.71-1.22)
  Placenta 450 0.01 385 0.18 19.90 (16.40-24.16)*** 8.74 (6.65-11.48)*** 1.59 (0.44-5.74)
  Endometrium 8094 0.21 835 0.39 1.36 (1.26-1.47)*** 1.28 (1.18-1.39)*** 1.32 (1.17-1.49)***
  Ovary 13406 0.35 873 0.41 1.02 (0.95-1.10) 1.02 (0.94-1.10) 0.85 (0.75-0.96)**
  Bladder 6043 0.16 1151 0.54 1.19 (1.11-1.27)*** 1.17 (1.09-1.25)*** 1.13 (1.03-1.25)*
  Kidney 6943 0.18 1471 0.68 1.38 (1.30-1.46)*** 1.36 (1.28-1.45)*** 1.32 (1.21-1.45)***
  Brain 6370 0.17 791 0.37 1.15 (1.06-1.25)*** 1.10 (1.01-1.20)* 0.80 (0.66-0.97)*
  Hodgkin’s disease 543 0.01 91 0.04 1.84 (1.44-2.35)*** 1.82 (1.38-2.39)*** 1.35 (0.64-2.87)
  Leukemia 3353 0.09 830 0.39 2.11 (1.94-2.29)*** 1.84 (1.68-2.03)*** 0.96 (0.83-1.12)
  Carcinoma in situ 49189 1.30 3142 1.47 0.93 (0.90-0.97)*** 0.92 (0.88-0.96)*** 1.05 (0.36-3.06)
  1. (a) The SIR for general population is 1.00.
  2. (b) Observed number of cancer cases for population with type 2 diabetes after exclusion of cancers diagnosed within 1 year of cohort entry.
  3. (c) Observed number of cancer cases for population with type 2 diabetes using Registry of Catastrophic Illness Database
  4. SIRs were adjusted for covariates (insurance premium, urbanization degree of area registered for National Health Insurance program, and age).
  5. Bold type indicates that the 95% CI does not include 1.00. Abbreviations: CI confidence interval, O observed number of cancer cases, SIR standardized incidence ratio. #: per 1000 person-years; *: p < 0.05; **: p < 0.01; ***: p < 0.001.