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Table 1 Clinicopathologic characteristics of colorectal cancer patients and methylation status of ADHFE1

From: Alcohol induces cell proliferation via hypermethylation of ADHFE1 in colorectal cancer cells

Characteristics

No. of cases

Methylation status of ADHFE1(PMR, %)

Median (range)

p-Value

Normal

73

3.25 (±0.50)

< 0.001

Colorectal cancer

73

74.89 (±8.06)

 

Age (years)

  

0.957

 ≤ 65

35

75.35 (±13.73)

 

 > 65

38

74.46 (±9.13)

 

Gender

  

0.114

 Female

27

91.55 (±16.46)

 

 Male

46

65.10 (±8.21)

 

Location

  

0.627

 Colon

46

77.91 (±10.45)

 

 Rectum

27

69.73 (±12.77)

 

TNM Stage

  

0.252

 I,II

32

85.40 (±14.10)

 

 III,IV

41

66.68 (±9.18)

 

Size (mm)

  

0.276

 ≤ 25

44

67.71 (±7.81)

 

 > 25

29

85.78 (±16.48)

 

Alcohol consumption

  

0.012

 Non-drinking

36

95.27 (±13.15)

 

 Drinking

37

55.06 (±8.41)

 
  1. Statistical significance is evaluated by analysis of variance (ANOVA). p-Values of < 0.05 are considered statistically significant.
  2. PMR: Percentage of methylated reference; TNM: Tumor, lymph nodes and metastasis.