Figure 1
From: Alcohol induces cell proliferation via hypermethylation of ADHFE1 in colorectal cancer cells
The methylation status and mRNA expression levels of ADHFE1 in CRC tissues and adjacent normal tissues. The methylation status of ADHFE1 in 73 CRC tissues and adjacent normal tissues is assessed using QMSP. A, C. ADHFE1 is hypermethylated in CRC (A) and also significantly hypermethylated in drinking groups and non-drinking groups (C). B. The expression levels of ADHFE1 in 73 CRC tissues compared with adjacent normal tissues was determined in 73 CRC tissues by real-time PCR. The mRNA expression of ADHFE1 is significantly decreased in CRC compared to adjacent normal tissues. D. The down regulation of ADHFE1 is presented in drinking groups and non-drinking groups. *,†p-Values of < 0.05 were considered statistically significant. AdjN: Adjacent normal tissue; T: Colorectal cancer tissues; PMR,: Percentage of methylated reference.