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Figure 5 | BMC Cancer

Figure 5

From: Thrombomodulin expression regulates tumorigenesis in bladder cancer

Figure 5

Level of TM in bladder cancer. (a) Immunohistochemical staining with anti-TM antibody on human bladder cancer specimens. Representative slides demonstrate that tumor cells showed TM-positive staining and that TM levels negatively correlated with clinical stage. (b) TM levels were negatively correlated with DNMT1 expression in human bladder cancer specimens (P  <  0.05). Representative slides of two selected tumor specimens demonstrating staining for both TM and DNMT1 are shown. (c) The effect of DNMT1 inhibition on the level of TM was examined by Western blots in cells transfected with the control vector (CV) and in cells transfected with the DNMT1 silencing vector (DM-). (d) Effect of DNMT inhibition on the level of TM was examined by IF analysis. The results from representative slides are shown (DAPI = blue; TM = green).

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