SAHA induces differentiation and inhibits migration of PaTu8988 cells
. (A) PaTu8988 cells were seeded on glass cover slips in six-well plate and treated with SAHA for 48 h. Cells were stained with Wright-Giemsa stain and photographed by oil microscopy for 1000×. (B) PaTu8988 cells were incubated with SAHA at indicated dosage for 24 h, the in vitro cell migration was analyzed by "scratch" assay as described, cell viability was analyzed by MTT assay (C). Experiments in this figure were repeated three times, and similar results were obtained. Magnification: 1:200 (B).