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Table 5 Risk of CRC and molecular subgroups in relation to HRT and ERT use in colon and rectum

From: Associations of hormone replacement therapy and oral contraceptives with risk of colorectal cancer defined by clinicopathological factors, beta-catenin alterations, expression of cyclin D1, p53, and microsatellite-instability

  Colon Rectum
Tumour subgroups HRT use n HR crude p HR adjusted p n HR crude p HR adjusted p
beta-catenin + No 68 1.00   1.00   51 1.00   1.00  
ERT 9 1.62(0.80-3.26) 0.180 1.52(0.74-3.16) 0.257 4 0.38(0.14-1.09) 0.073 1.00(0.45-2.25) 1.000
CHRT 11 0.88(0.46-1.67) 0.696 0.96(0.48-1.91) 0.910 8 0.44(0.19-1.02) 0.054 1.00(0.44-2.26) 1.000
beta-catenin − No 64 1.00   1.00   17 1.00   1.00  
ERT 4 0.76(0.27-2.09) 0.588 0.71(0.25-1.97) 0.506 3 0.87(0.24-3.12) 0.833 1.00(0.27-3.73) 1.000
CHRT 10 0.91(0.46-1.78) 0.779 0.92(0.45-1.88) 0.808 3 0.41(0.09-1.83) 0.242 1.00(0.25-3.95) 1.000
cyclin D1 + No 120 1.00   1.00   50 1.00   1.00  
ERT 10 1.04(0.54-1.98) 0.917 0.96(0.49-1.86) 0.895 6 0.56(0.23-1.34) 0.189 0.44(0.17-1.14) 0.091
CHRT 18 0.86(0.52-1.42) 0.557 0.95(0.56-1.62) 0.854 11 0.60(0.28-1.28) 0.188 0.51(0.21-1.24) 0.135
cyclin D1 − No 15 1.00   1.00   16 1.00   1.00  
ERT 3 2.05(0.59-7.10) 0.260 2.34(0.65-8.44) 0.196 1 0.37(0.05-2.81) 0.334 0.28(0.03-2.27) 0.232
CHRT 4 1.33(0.44-4.05) 0.615 1.50(0.46-4.94) 0.504 1 0.19(0.02-1.56) 0.124 0.07(0.01-0.88) 0.039
p53 + No 54 1.00   1.00   40 1.00   1.00  
ERT 6 1.38(0.59-3.24) 0.454 1.27(0.53-3.02) 0.588 5 0.54(0.21-1.41) 0.208 1.00(0.43-2.35) 1.000
CHRT 9 0.94(0.46-1.92) 0.869 1.02(0.48-2.20) 0.951 9 0.56(0.25-1.27) 0.168 1.00(0.42-2.40) 1.000
p53 − No 82 1.00   1.00   26 1.00   1.00  
ERT 7 1.02(0.47-2.21) 0.968 0.95(0.43-2.11) 0.903 2 0.47(0.11-2.02) 0.308 0.23(0.05-1.18) 0.078
CHRT 13 0.89(0.49-1.61) 0.703 1.00(0.54-1.86) 0.996 3 0.36(0.09-1.54) 0.170 0.19(0.04-0.96) 0.044
MSI No 36 1.00   1.00   2 1.00   1.00  
ERT 1 0.36(0.05-2.67) 0.320 0.28(0.04-2.08) 0.212 0 -   -  
CHRT 5 0.84(0.32-2.16) 0.710 0.90(0.34-2.40) 0.832 0 -   -  
MSS No 97 1.00   1.00   64 1.00   1.00  
ERT 11 1.35(0.72-2.53) 0.349 1.36(0.71-2.60) 0.352 7 0.54(0.24-1.22) 0.138 1.00(0.49-2.03) 1.000
  CHRT 17 0.98(0.58-1.65) 0.943 1.08(0.62-1.89) 0.789 11 0.46(0.22-0.97) 0.041 1.00(0.49-2.05) 1.000
  1. Adjusted for age, bmi, educational level, smoking habits and alcohol consumption.