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Table 5 Risk of CRC and molecular subgroups in relation to HRT and ERT use in colon and rectum

From: Associations of hormone replacement therapy and oral contraceptives with risk of colorectal cancer defined by clinicopathological factors, beta-catenin alterations, expression of cyclin D1, p53, and microsatellite-instability

 

Colon

Rectum

Tumour subgroups

HRT use

n

HR crude

p

HR adjusted

p

n

HR crude

p

HR adjusted

p

beta-catenin +

No

68

1.00

 

1.00

 

51

1.00

 

1.00

 

ERT

9

1.62(0.80-3.26)

0.180

1.52(0.74-3.16)

0.257

4

0.38(0.14-1.09)

0.073

1.00(0.45-2.25)

1.000

CHRT

11

0.88(0.46-1.67)

0.696

0.96(0.48-1.91)

0.910

8

0.44(0.19-1.02)

0.054

1.00(0.44-2.26)

1.000

beta-catenin −

No

64

1.00

 

1.00

 

17

1.00

 

1.00

 

ERT

4

0.76(0.27-2.09)

0.588

0.71(0.25-1.97)

0.506

3

0.87(0.24-3.12)

0.833

1.00(0.27-3.73)

1.000

CHRT

10

0.91(0.46-1.78)

0.779

0.92(0.45-1.88)

0.808

3

0.41(0.09-1.83)

0.242

1.00(0.25-3.95)

1.000

cyclin D1 +

No

120

1.00

 

1.00

 

50

1.00

 

1.00

 

ERT

10

1.04(0.54-1.98)

0.917

0.96(0.49-1.86)

0.895

6

0.56(0.23-1.34)

0.189

0.44(0.17-1.14)

0.091

CHRT

18

0.86(0.52-1.42)

0.557

0.95(0.56-1.62)

0.854

11

0.60(0.28-1.28)

0.188

0.51(0.21-1.24)

0.135

cyclin D1 −

No

15

1.00

 

1.00

 

16

1.00

 

1.00

 

ERT

3

2.05(0.59-7.10)

0.260

2.34(0.65-8.44)

0.196

1

0.37(0.05-2.81)

0.334

0.28(0.03-2.27)

0.232

CHRT

4

1.33(0.44-4.05)

0.615

1.50(0.46-4.94)

0.504

1

0.19(0.02-1.56)

0.124

0.07(0.01-0.88)

0.039

p53 +

No

54

1.00

 

1.00

 

40

1.00

 

1.00

 

ERT

6

1.38(0.59-3.24)

0.454

1.27(0.53-3.02)

0.588

5

0.54(0.21-1.41)

0.208

1.00(0.43-2.35)

1.000

CHRT

9

0.94(0.46-1.92)

0.869

1.02(0.48-2.20)

0.951

9

0.56(0.25-1.27)

0.168

1.00(0.42-2.40)

1.000

p53 −

No

82

1.00

 

1.00

 

26

1.00

 

1.00

 

ERT

7

1.02(0.47-2.21)

0.968

0.95(0.43-2.11)

0.903

2

0.47(0.11-2.02)

0.308

0.23(0.05-1.18)

0.078

CHRT

13

0.89(0.49-1.61)

0.703

1.00(0.54-1.86)

0.996

3

0.36(0.09-1.54)

0.170

0.19(0.04-0.96)

0.044

MSI

No

36

1.00

 

1.00

 

2

1.00

 

1.00

 

ERT

1

0.36(0.05-2.67)

0.320

0.28(0.04-2.08)

0.212

0

-

 

-

 

CHRT

5

0.84(0.32-2.16)

0.710

0.90(0.34-2.40)

0.832

0

-

 

-

 

MSS

No

97

1.00

 

1.00

 

64

1.00

 

1.00

 

ERT

11

1.35(0.72-2.53)

0.349

1.36(0.71-2.60)

0.352

7

0.54(0.24-1.22)

0.138

1.00(0.49-2.03)

1.000

 

CHRT

17

0.98(0.58-1.65)

0.943

1.08(0.62-1.89)

0.789

11

0.46(0.22-0.97)

0.041

1.00(0.49-2.05)

1.000

  1. Adjusted for age, bmi, educational level, smoking habits and alcohol consumption.