The nucleolar size is associated to the methylation status of ribosomal DNA in breast carcinomas

Bacalini, Maria Giulia; Pacilli, Annalisa; Giuliani, Cristina; Penzo, Marianna; Treré, Davide; Pirazzini, Chiara; Salvioli, Stefano; Franceschi, Claudio; Montanaro, Lorenzo; Garagnani, Paolo

doi:10.1186/1471-2407-14-361

BMC Cancer

Table 2 ANOVA test of association between rDNA methylation and clinical and pathological parameters

From: The nucleolar size is associated to the methylation status of ribosomal DNA in breast carcinomas

CpG unit	Age	Histotype	Grade	Nuclear grade	Diameter	pT	p53	ER	PR	Ki67	Nucleolar size
Ribo_CpG_5	0.74	0.16	0.37	0.02	0.89	0.93	0.57	0.67	0.96	0.58	0.04
Ribo_CpG_17.18	0.70	0.12	0.28	0.08	0.70	0.74	0.79	0.62	0.91	1.00	0.09
Ribo_CpG_19.20	0.65	0.11	0.52	0.16	0.67	0.67	0.54	0.91	0.83	0.74	0.04
Ribo_CpG_21	0.72	0.09	0.33	0.13	0.61	0.59	0.55	0.92	0.73	0.77	0.05
Ribo_CpG_22.23	0.70	0.12	0.28	0.08	0.70	0.74	0.79	0.62	0.91	1.00	0.09
Ribo_CpG_24.25	0.92	0.20	0.38	0.04	0.55	0.75	0.57	0.95	0.80	0.88	0.02
Ribo_CpG_26	0.96	0.26	0.73	0.26	0.60	0.67	0.31	0.52	0.42	0.46	0.01
X18S_CpG_1	0.59	0.07	0.45	0.18	0.82	0.73	0.34	0.74	0.91	0.87	0.21
X18S_CpG_2	0.87	0.07	0.47	0.14	0.84	0.87	0.43	0.93	0.82	0.82	0.06
X18S_CpG_4	0.52	0.06	0.40	0.05	0.97	0.85	0.60	0.58	0.88	0.67	0.14
X18S_CpG_5	0.63	0.13	0.39	0.04	0.94	0.94	0.51	0.76	0.99	0.39	0.15
X18S_CpG_9.10	0.86	0.47	0.25	0.04	0.51	0.54	0.46	0.96	0.81	0.85	0.05
X18S_CpG_11.12.13	0.57	0.09	0.17	0.01	0.64	0.85	0.90	0.52	0.75	0.44	0.08
X18S_CpG_14.15.16	0.62	0.13	0.21	0.02	0.96	0.99	0.83	0.54	0.81	0.32	0.20
X18S_CpG_17.18	0.45	0.21	0.34	0.03	0.87	0.82	0.76	0.61	0.90	0.42	0.18
X18S_CpG_26	0.53	0.09	0.45	0.13	0.91	0.72	0.73	0.56	0.86	0.86	0.20
X18S_CpG_28.29	0.54	0.15	0.14	0.01	0.87	0.80	0.80	0.21	0.38	0.27	0.24
X18S_CpG_30.31.32	0.76	0.21	0.22	0.05	0.73	0.79	0.85	0.39	0.64	0.72	0.12
X18S_CpG_35	0.92	0.85	0.99	0.96	0.25	0.26	0.21	0.39	0.39	0.83	0.25
X18S_CpG_36.37.38	0.76	0.21	0.22	0.05	0.73	0.79	0.85	0.39	0.64	0.72	0.12
X28S_CpG_1	0.57	0.12	0.29	0.02	0.78	0.90	0.64	0.80	0.95	0.56	0.06
X28S_CpG_2	0.78	0.63	0.62	0.86	0.79	0.73	0.19	0.14	0.19	0.16	0.10
X28S_CpG_3	0.41	0.13	0.45	0.13	0.79	0.81	0.81	0.55	0.82	0.79	0.14
X28S_CpG_10	0.83	0.11	0.44	0.08	0.54	0.65	0.65	0.88	0.95	0.89	0.07
X28S_CpG_11	0.81	0.25	0.40	0.06	0.93	1.00	0.84	0.81	0.99	0.94	0.08
X28S_CpG_12.13	0.74	0.13	0.46	0.08	0.97	0.89	0.40	0.91	0.60	0.82	0.05
X28S_CpG_15.16.17	0.60	0.21	0.33	0.03	0.82	0.95	0.67	0.79	0.98	0.81	0.08
X28S_CpG_18.19	0.75	0.17	0.46	0.08	0.84	0.83	0.52	0.95	0.80	0.97	0.03
X28S_CpG_20	0.78	0.63	0.62	0.86	0.79	0.73	0.19	0.14	0.19	0.16	0.10
X28S_CpG_29.30	0.75	0.16	0.42	0.08	0.74	0.86	0.46	0.79	0.62	0.78	0.04

p-values less than 0.05 are reported in bold.

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