Table 2 Results of the multivariate cox proportional hazards model
Overall survival | ||
|---|---|---|
HR (95% CI) | p value | |
Gender | ||
Male v. female | 0.99 (0.68-1.43) | 0.9 |
Age (years) | ||
≥ 75 v. < 75 | 1.11 (0.75-1.63) | 0.6 |
ECOG PS | ||
1 vs. 2 | 2.04 (1.38-3.01) | 0.0003 |
Weight loss | ||
≥5% vs. <5% | 1.01 (0.59-1.35) | 0.6 |
Anemia | ||
Hb <10 gr/dl vs. ≥10gr/dl | 1.10 (0.75-1.62) | 06 |
Albumin | ||
≤3.5 vs. >3.5 gr/dl | 1.01 (0.71-1.45) | 0.9 |
CEA level | ||
≥ 5 ng/ml vs. < 5 ng/ml | 1.33 (0.91-1-94) | 0.1 |
Tumor grading | ||
G3 vs. G1-2 | 0.93 (0.67-1.28) | 0.6 |
Histotype | ||
Diffuse vs. intestinal | 1.03 (0.69-1.52) | 0.8 |
First line response rate | ||
PD + SD vs. CR + PR | 1.76 (1.21-2.54) | 0.002 |
Liver metastasis | ||
Present vs. absent | 1.33 (0.89-1.98) | 0.1 |
LA/LR | ||
Yes vs. no | 0.75 (0.51-1.09) | 0.1 |
Peritoneal metastasis | ||
Present vs. absent | 1.50 (1.02-2.21) | 0.03 |
Number of metastatic sites | ||
>2 vs. 1-2 | 1.90 (1.22-2.96) | 0.004 |
rs1800795 genotypes | ||
G/G vs. other | 1.69 (1.88-2.42) | 0.003 |
rs8192284 genotypes | ||
C/C vs. other | 1.78 (1.12-2.83) | 0.01 |