Table 4 Colorectal cancer anatomical location, TNM stage, treatment and follow-up, in the different AAT-Pi phenotypes
AAT Pi* genotype | ||||||
|---|---|---|---|---|---|---|
Total n (%) | Pi*MM n (%) | Pi*MS n (%) | Pi*MZ n (%) | Pi*SZ n (%) | P | |
Location | 0.822 | |||||
Ascending colon | 50 (19) | 40 (19) | 7 (14) | 3 (30) | 0 (0) | |
Transverse colon | 22 (8) | 18 (9) | 3 (6) | 1 (10) | 0 (0) | |
Descending colon | 30 (11) | 24 (12) | 4 (8) | 2 (20) | 0 (0) | |
Sigmoid colon | 91 (34) | 68 (33) | 21 (43) | 1 (10) | 1 (100) | |
Rectum | 74 (28) | 57 (27) | 14 (29) | 3 (30) | 0 (0) | |
TNM stage | 0.409 | |||||
I | 33 (12) | 25 (12) | 6 (12) | 2 (20) | 0 (0) | |
II | 124 (47) | 92 (44) | 29 (59) | 2 (20) | 1 (100) | |
III | 85 (32) | 71 (34) | 9 (19) | 5 (50) | 0 (0) | |
IV | 25 (9) | 19 (10) | 5 (10) | 1 (10) | 0 (0) | |
Treatment | ||||||
Surgery | 255 (96) | 197 (95) | 47 (96) | 10 (100) | 1 (100) | 1.000 |
Chemotherapy | 79 (30) | 63 (30) | 10 (20) | 6 (60) | 0 (0) | 0.058 |
Radiation | 43 (16) | 31 (15) | 9 (18) | 3 (30) | 0 (0) | 0.559 |
Chemoradiotherapy | 20 (8) | 16 (8) | 3 (6) | 1 (10) | 0 (0) | 0.921 |
Palliative care | 12 (4) | 10 (5) | 2 (4) | 0 (0) | 0 (0) | NA |
Deaths | 62 (23) | 45 (22) | 14 (29) | 3 (30) | 0 (0) | NA |
CRC-related | 46 (17) | 33 (16) | 10 (20) | 3 (30) | 0 (0) | NA |
Other causes of death: | 16 (6) | 12 (6) | 4 (8) | 0 (0) | 0 (0) | NA |
Acute myocardial infarction | 3 | 2 | 1 | NA | ||
Congestive heart failure | 1 | 1 | NA | |||
Gastrointestinal bleeding | 2 | 2 | NA | |||
Postsurgical sepsis | 3 | 3 | NA | |||
Post-chemotherapy sepsis | 2 | 2 | NA | |||
Diffuse non-Hodgkin’s lymphoma | 1 | 1 | NA | |||
Pulmonary thromboembolism | 2 | 2 | NA | |||
Brain stroke | 1 | 1 | NA | |||
Hepatic failure liver cirrhosis-related | 1 | 1 | NA | |||