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Figure 7 | BMC Cancer

Figure 7

From: Tumors induce coordinate growth of artery, vein, and lymphatic vessel triads

Figure 7

Large vessel triads containing artery, vein, and lymphatics arise in autochthonous tumors. a). The dorsal skin of a control mouse. b). The dorsal skin of a p19Arf+/- mouse bearing DMBA/TPA- induced papillomas. c). The dorsal skin of a p19Arf+/- mouse bearing DMBA/TPA-induced invasive carcinomas. d). Normal ventral skin is relatively avascular with sparse and very small blood vessels. e). Ventral skin beneath the papillomas (b) shows highly abnormal and enlarged red-colored vessels. f). The ventral skin beneath the carcinomas (c) shows highly abnormal and enlarged red-colored vessels. g). MECA-32 immunohistochemical staining of a papilloma-associated vessel from a p19Arf+/- mouse identifies large veins and thick walled arteries. h). 10.1.1 immunohistochemical staining of the same papilloma-associated vessel (g) identifies five lymphatic vessels. i). CD31 immunohistochemical staining of a carcinoma-associated vessel from a wild-type mouse identifies large lymphatics, vein, and artery. j). 10.1.1 immunohistochemical staining of the same carcinoma-associated vessel (i) identifies 2 lymphatic vessels. k). CD31 immunohistochemical staining of a carcinoma-associated vessel from another wild-type mouse identifies disorganized cluster of enlarged blood and lymphatic vessels. l). 10.1.1 immunohistochemical staining of the same carcinoma-associated vessel (k) identifies clustered enlarged lymphatic vessels. Scale bar 50 μm.

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