Excellent local control with IOERT and postoperative EBRT in high grade extremity sarcoma: results from a subgroup analysis of a prospective trial

Table 6 Results of major IORT series

Author	Year	n	f/u	R0 (%)	IORT	EBRT	5-y-LC	5-y-OS	LP (%)	FC (%)
Edmonson [13]	2001	39	70	62	10-20	45	90*	80	95	n.r.
Azinovic [14]	2003	45	93	67	15	45-50	80*	64*	88	77
Kretzler [15]	2004	28	52	61	12-15	50	84	66	100	59
Llacer [17]	2006	79	58	42	20 (LDR)	45-50	90	69	100	n.r.
Oertel [16]	2006	128°	33	49	15	45	83	83	90	86
Alvarez [18]	2008	53	66	n.r.	7.5-12.5	n.r.	87	75	83	81
Current Study	2013	34	43	88	10-15	40-50	97	79	94	81

n: number of patients, f/u: median follow up,%: percentage, R0: rate of microscopic complete resections, IORT: intraoperative radiation therapy dose in Gy, EBRT: external beam radiation therapy dose in Gy, 5-y-LC: estimated 5-year-local control rate in%, 5-y-OS: estimated 5-year-overall survival rate in%, LP: limb preservation rate, FC (%): rate of excellent/good functional outcome, *: crude rates, °: excluding patients with distant metastases at time of surgery.

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