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Table 6 Results of major IORT series

From: Excellent local control with IOERT and postoperative EBRT in high grade extremity sarcoma: results from a subgroup analysis of a prospective trial

Author Year n f/u R0 (%) IORT EBRT 5-y-LC 5-y-OS LP (%) FC (%)
Edmonson [13] 2001 39 70 62 10-20 45 90* 80 95 n.r.
Azinovic [14] 2003 45 93 67 15 45-50 80* 64* 88 77
Kretzler [15] 2004 28 52 61 12-15 50 84 66 100 59
Llacer [17] 2006 79 58 42 20 (LDR) 45-50 90 69 100 n.r.
Oertel [16] 2006 128° 33 49 15 45 83 83 90 86
Alvarez [18] 2008 53 66 n.r. 7.5-12.5 n.r. 87 75 83 81
Current Study 2013 34 43 88 10-15 40-50 97 79 94 81
  1. n: number of patients, f/u: median follow up,%: percentage, R0: rate of microscopic complete resections, IORT: intraoperative radiation therapy dose in Gy, EBRT: external beam radiation therapy dose in Gy, 5-y-LC: estimated 5-year-local control rate in%, 5-y-OS: estimated 5-year-overall survival rate in%, LP: limb preservation rate, FC (%): rate of excellent/good functional outcome, *: crude rates, °: excluding patients with distant metastases at time of surgery.