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Figure 1 | BMC Cancer

Figure 1

From: Matrix metalloproteinase 12 is induced by heterogeneous nuclear ribonucleoprotein K and promotes migration and invasion in nasopharyngeal carcinoma

Figure 1

Identification of hnRNP K-targeted MMPs. (A) Affymetrix cDNA microarrays were used to examine the gene expression levels of MMP1, MMP12, MMP13 and MMP28 in hnRNP K-knockdown versus control siRNA-transfected NPC-TW02 cells. (B) Verification of hnRNP K-regulated MMP gene expression in NPC cells. NPC-TW02 cells were transfected with either hnRNP K-targeting (K) or control (C) siRNA. Cells were harvested post-transfection 48 h to detect the MMPs mRNA expression levels by quantitative RT-PCR analyses. All data are presented as the mean ± SD from three experiments. *P < 0.05. (C) Affymetrix cDNA microarrays were used to examine the gene expression levels of MMP1, MMP12, MMP13 and MMP28 in NPC tumor versus adjacent normal tissues. (D) Quantitative RT-PCR analyses of MMP gene expression in nine matched-pairs of NPC tumor and adjacent normal tissues.

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