Temporal evolution in caveolin 1 methylation levels during human esophageal carcinogenesis

Jin, Zhe; Wang, Liang; Cao, Ziyi; Cheng, Yulan; Gao, Yan; Feng, Xianling; Chen, Si; Yu, Huimin; Wu, Wenjing; Zhao, Zhenfu; Dong, Ming; Zhang, Xiaojing; Liu, Jie; Fan, Xinmin; Mori, Yuriko; Meltzer, Stephen J

doi:10.1186/1471-2407-14-345

BMC Cancer

Table 1 Clinicopathologic characteristics and methylation status of Caveolin 1 in human esophageal tissues

From: Temporal evolution in caveolin 1 methylation levels during human esophageal carcinogenesis

	Number of samples	Age (year) mean	NMV		Methylation status (cutoff 0.2)
Clinical characteristics			Mean	p	Frequency	UM	M	p
Barrett’s segment
Short-segment ( <3 cm )	14	62.3	0.327	>0.05^§	71.4%	4	10	> 0.05^‡
Long-segment ( > = 3 cm )	16	62.8	0.439		81.3%	3	13
Histology
Normal esophagus	67	64.4	0.134		25.4%	50	17
Barrett’s metaplasia	60	63.7	0.374	< 0.01*^/§	81.7%	11	49	* < 0.01^†
Dysplasia in Barrett’s esophagus	40	65.3	0.254	< 0.01*^/§/ < 0.01^$/§	60.0%	16	24	* < 0.01^†/ ^$ < 0.05^†
Low-grade dysplasia	19	65.3	0.269	< 0.01*^/§/ < 0.05^$/§	57.9%	8	11	* < 0.01^†/ ^$ < 0.05^†
High-grade dysplasia	21	65.2	0.240	< 0.01*^/§/ < 0.01^$/§	61.9%	8	13	* < 0.01^†/ ^$ > 0.05^†
EAC	67	65.1	0.294	< 0.01*^/§/ < 0.01^$/§	65.7%	23	44	* < 0.01^†/ ^$ < 0.05^†
Well differentiation	10	66.2	0.344	>0.05^§§	80.0%	2	8	> 0.05^‡
Moderate differentiation	24	66.1	0.29		58.3%	10	14
Poor differentiation	22	65.5	0.297		63.6%	8	14
Unknown	11	61	0.252		72.7%	3	8
ESCC	26	62.5	0.326	< 0.01*^/§	80.8%	5	21	* < 0.01^‡
Well differentiation	3	61.7	0.307	>0.05^§§	100.0%	0	3	> 0.05^‡
Moderate differentiation	11	62.7	0.381		90.9%	1	10
Poor differentiation	5	64.2	0.256		80.0%	1	4
Unknown	7	61.1	0.299		57.1%	3	4
Stage of EAC patients
I	7	63	0.358	>0.05^§§	71.4%	2	5	> 0.05^‡
II	15	65.2	0.286		73.3%	4	11
III	25	64.6	0.284		56.0%	11	14
IV	7	66.3	0.242		28.6%	5	2
Lymph node metastasis in EAC patients
Negative	25	64.9	0.314	>0.05^§	64.0%	9	16	> 0.05^†
Positive	25	64.6	0.276		56.0%	11	14
Smoking status of EAC patients
Never	6	58.5	0.325	>0.05^§§	83.3%	1	5	> 0.05^‡
Former	24	68.5	0.276		62.5%	9	15
Current	13	60.8	0.303		53.8%	6	7
Alcohol consumption of EAC patients
Never	16	65.3	0.285	>0.05^§§	68.8%	5	11	> 0.05^‡
Former	15	63	0.302		66.7%	5	10
Current	10	65.7	0.315		60.0%	4	6

EAC: esophageal adenocarcinoma; ESCC: esophageal squamous cell carcinoma; NMV: normalized methylation value; UM, unmethylated; M, methylated; ^§Student's t test; *comparisons made to normal esophagus; *comparisons made to Barrett’s metaplasia; ^§§Kruskal-Wallis test; ^†Chi-square for independence test; ^‡Fisher's exact test.

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ISSN: 1471-2407

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