Figure 3

Methylation profiles of CAV1 in different esophageal tissue samples. A, The mean NMV of CAV1 was significantly higher in ESCC, EAC, D, and BE than in NE, and in BE than in D and EAC. B. The frequency of CAV1 hypermethylation was significantly higher in BE, D, EAC and ESCC than in NE, and in BE than in D and EAC. NE: normal esophagus; BE: Barrett’s metaplasia; D: Dysplasia in BE; EAC: esophageal adenocarcinoma; ESCC: esophageal squamous cell carcinoma; *: Student’s t test, p < 0.01 (comparisons made to NE); $: Student’s t test, p < 0.01 (comparisons made to BE); †: Chi-square for independence test, p < 0.01 (comparisons made to NE); ‡: Fisher’s exact test, p < 0.01 (comparisons made to NE); §: Chi-square for independence test, p < 0.05 (comparisons made to BE).