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Table 3 Mutation distribution in the family

From: Genome instability in blood cells of a BRCA1 + breast cancer family

Gene Position Base change AA change Sister #1 Sister #2 Sister #4 Sister #3
     Cancer Cancer Cancer Unaffected
A. Mutation distribution in the three breast cancer-affected sisters
PHKG2 chr16:30767746 c.C706T p.R236W + + + -
GSTK1 chr7:142964824 c.G703A p.G235R + + - -
ITGA1 chr5:52240783 c.C3296G p.S1099C + + - -
PAMR1 chr11:35456266 c.G1420A p.G474R + + - -
TMPRSS7 chr3:111797705 c.G1963A p.G655S + + - -
UEVLD chr11:18553971 c.G1312T p.V438L + + - -
LACRT chr12:55028594 c.C32T p.A11V + - + -
SRA1 chr5:139936828 c.C91T p.P31S + - + -
ZNF24 chr18:32919897 c.T464G p.M155R + - + -
ABLIM2 chr4:8055946 c.G791A p.R264Q - + + -
FOXP1 chr3:71247489 c.C44T p.A15V - + + -
TTN chr2:179400887 c.G73392A p.W24464X - + + -
CACNB3 chr12:49220218 c.G688A p.A230T - + - -
CHCHD1 chr10:75541868 c.G35T p.R12L - + - -
B. Mutation distribution between generations
Pair 1 Father #9 Mother #2 Daughter #5 Daughter #6
RAB3C chr5:58147140 c.G646A p.E216K - + + +
SRA1 chr5:139936828 c.C91T p.P31S - + + +
TMPRSS7 chr3:111797705 c.G1963A p.G655S - + + +
ZNF24 chr18:32919897 c.T464G p.M155R - + + +
LACRT chr12:55028594 c.C32T p.A11V - + + -
PAMR1 chr11:35456266 c.G1420A p.G474R - + + -
GSTK1 chr7:142964824 c.G703A p.G235R - + - +
PHKG2 chr16:30767746 c.C706T p.R236W - + - +
UEVLD chr11:18553971 c.G1312T p.V438L - + - +
ITGA1 chr5:52240783 c.C3296G p.S1099C - + - -
BPTF chr17:65850386 c.A944C p.N315T - - + -
TBC1D22B chr6:37280778 c.G1067A p.S356N - - + -
SEMA3C chr7:80374250 c.G2216A p.R739Q - - + -
CUL4B chrX:119680410 c.A838T p.R280X - - + -
CLCN4 chrX:10176455 c.G1214A p.C405Y - - + -
LAT chr16:29000901 c.G634T p.A212S - - + -
ZNF304 chr19:57868409 c.A1172T p.Y391F - - + -
ZNF674 chrX:46359537 c.C1487A p.P496H - - + -
KCTD8 chr4:44177010 c.C1219T p.R407C - - + -
Pair 2 Father #10 Mother #4 Daughter #7 Son #8
SRA1 chr5:139936828 c.C91T p.P31S - + + +
PHKG2 chr16:30767746 c.C706T p.R236W - + + -
CASQ1 chr1:160165804 c.G769A p.E257K - + + -
ABLIM2 chr4:8055946 c.G791A p.R264Q - + + -
TTN chr2:179400887 c.G73392A p.W24464X - + + -
FOXP1 chr3:71247489 c.C44T p.A15V - + + -