From: The chick chorioallantoic membrane as an in vivo xenograft model for Burkitt lymphoma
Feature/host | Chick (CAM xenograft) | Mouse ((NOD-) SCID xenograft) | Human |
---|---|---|---|
Characteristics of BL tumors | |||
Formation of solid tumors | +[3] | ||
Lymphogenic dissemination | +[27] | +[29] | |
Distant organ metastasis | Not yet reported | +[27] | +[30] |
Macrophage infiltration of tumor (‘starry sky’) | +[32] | ||
Tumor cell morphology | -Blast-like | -Blast-like | - Blast-like |
-Basophilic cytoplasm | -Basophilic cytoplasm | - Basophilic cytoplasm | |
-Lipid vacuoles | -Lipid vacuoles | -Lipid vacuoles | |
-Prominent nucleoli [33] | -Prominent nucleoli [34] | ||
Lymphatic/blood vessel formation | -/+[18] | ||
Ki67+% of tumor cells | >90% (Figure 1E) | >90% [31] | 90-100% [37] |
Experimental parameters | |||
Immune status of host | Weakly immunocompetent (developing immune system) | Immunodeficient (depletion of B- and T-cells) | Mature immune system |
Investigation period | Max. 8 -9 days | Weeks - months | Weeks - years |
Bureaucratic efforts | None* | Medium (Animal experiment) | High (Clinical trial) |
Premises | Incubator, Cell culture and imaging devices | Animal facility, Cell culture and imaging devices | Fully equipped hospital and staff |
Costs/n | 2 $ | 100 $[38] | −11000 $[39] |