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Table 3 Crude and adjusted hazard ratio (95% CI) of risk factors for death by univariate and multivariate cox regression analysis

From: Health-related quality of life and risk of colorectal cancer recurrence and All-cause death among advanced stages of colorectal cancer 1-year after diagnosis

 

Crude HRa

Adjusted HR (FACT-C domain)a

Adjusted HR (SF-12 domain)a

Adjusted HR (SF-6D)a

 

Estimate

95% CI

P-value

Estimate

95% CI

P-value

Estimate

95% CI

P-value

Estimate

95% CI

P-value

Primary Tumour Site (Colon)

            

  Rectum

1.213

(0.438,3.361)

0.710

1.033

(0.233,4.589)

0.966

0.561

(0.054,5.855)

0.629

0.720

(0.212,2.454)

0.600

Active CRC Treatment (No)

            

  Yes

1.633

(0.569,4.682)

0.362

1.039

(0.195,5.529)

0.964

0.424

(0.052,3.432)

0.421

1.007

(0.239,4.243)

0.993

Stoma (Present)

            

  Absent

0.812

(0.181,3.644)

0.785

1.714

(0.212,13.840)

0.613

0.046

(0.000,4.874)

0.195

1.165

(0.189,7.168)

0.869

Time Since Diagnosis, months

0.993

(0.974,1.011)

0.427

0.998

(0.976,1.020)

0.839

1.015

(0.992,1.040)

0.199

1.003

(0.983,1.023)

0.801

AJCC (Stage III)

            

  Stage IV

1.898

(0.688,5.242)

0.216

1.928

(0.365,10.193)

0.440

2.791

(0.319,24.446)

0.354

1.659

(0.371,7.411)

0.508

FACT-C

            

  PWB

0.966

(0.862,1.083)

0.557

1.076

(0.857,1.352)

0.527

      

  SWB

0.908

(0.820,1.006)

0.066

1.011

(0.870,1.174)

0.889

      

  EWB

0.965

(0.825,1.129)

0.657

0.929

(0.683,1.264)

0.639

      

  FWB

0.905

(0.819,1.001)

0.053

0.902

(0.722,1.128)

0.365

      

  CCS

1.008

(0.862,1.179)

0.921

0.996

(0.796,1.247)

0.972

      

SF-12

            

  PF

0.975

(0.960,0.991)

0.003b

   

0.917

(0.852,0.986)

0.019b

   

  RP

0.975

(0.956,0.994)

0.009b

   

0.996

(0.944,1.051)

0.882

   

  BP

0.994

(0.976,1.013)

0.552

   

1.055

(1.000,1.113)

0.052

   

  GH

0.970

(0.948,0.992)

0.008b

   

0.846

(0.746,0.958)

0.009b

   

  VT

1.005

(0.976,1.034)

0.754

   

1.151

(1.027,1.289)

0.015b

   

  SF

0.987

(0.972,1.003)

0.109

   

1.015

(0.970,1.063)

0.523

   

  RE

1.001

(0.975,1.027)

0.944

   

0.983

(0.919,1.051)

0.617

   

  MH

1.016

(0.975,1.058)

0.457

   

1.128

(1.005,1.265)

0.040b

   

SF-6D

0.007

(0.000,0.273)

0.008b

      

0.010

(0.000,0.573)

0.026b

AIC

   

128.2

111.2

131.4

BIC

   

187.3

179.8

179.1

Harrell’s C-statistic

   

0.824 (0.681,0.968)

0.956 (0.909,1.002)

0.799 (0.678,0.921)

  1. Note: HR = Hazard ratio.
  2. FACT-C subscales: PWB = physical well-being; SWB = social well-being; EWB = emotional well-being; FWB = functional well-being; CCS = colorectal cancer subscale;
  3. SF-12 subscales: PF = physical functioning; RP = role physical; BP = bodily pain; GH = general health; VT = vitality; SF = social functioning; RE = role emotional; MH = mental health.
  4. aHR > 1 indicates greater risk for death, with adjustment of socio-demographic characteristics.
  5. bp-value < 0.05.