Health-related quality of life and risk of colorectal cancer recurrence and All-cause death among advanced stages of colorectal cancer 1-year after diagnosis

Wong, Carlos KH; Law, Wai-Lun; Wan, Yuk-Fai; Poon, Jensen Tung-Chung; Lam, Cindy Lo-Kuen

doi:10.1186/1471-2407-14-337

Table 2 Health-related Quality of Life in different levels of clinical characteristics

Clinical characteristics	FACT-C^c					SF-12^c
	PWB	SWB	EWB	FWB	CCS	PF	RP	BP	GH	VT	SF	RE	MH	SF-6D^c
Overall	25.2 ± 3.8	20.2 ± 4.2	21.0 ± 3.1	18.7 ± 4.0	21.6 ± 3.4	75.2 ± 29.9	72.5 ± 27.8	84.2 ± 25.2	52.2 ± 26.6	66.0 ± 17.9	77.2 ± 30.4	88.6 ± 19.9	80.1 ± 14.7	0.81 ± 0.13
AJCC Stage
Stage III (n = 115)	25.5 ± 3.3	20.0 ± 4.4	21.1 ± 3.0	19.0 ± 4.1	21.3 ± 3.4	75.7 ± 30.5	74.2 ± 26.4	83.8 ± 25.9	52.4 ± 26.2	65.7 ± 17.8	78.8 ± 29.4	89.6 ± 18.3	80.1 ± 14.3	0.82 ± 0.13
Stage IV (n = 45)	24.5 ± 4.6	20.5 ± 3.8	20.9 ± 3.3	18.1 ± 3.9	22.3 ± 3.3	73.9 ± 28.7	68.6 ± 30.9	85.0 ± 23.5	51.8 ± 27.8	66.7 ± 18.5	73.3 ± 32.6	86.1 ± 23.3	80.0 ± 15.9	0.79 ± 0.14
P-value	0.142	0.536	0.720	0.238	0.123	0.733	0.264	0.792	0.899	0.767	0.313	0.321	0.964	0.225
Primary Tumour Site
Colon (n = 90)	25.5 ± 3.4	20.5 ± 3.7	21.2 ± 3.0	18.6 ± 4.2	22.2 ± 2.9	77.6 ± 29.7	73.7 ± 26.6	84.6 ± 25.5	53.5 ± 28.4	67.2 ± 18.1	79.1 ± 29.4	87.8 ± 20.6	82.3 ± 13.2	0.81 ± 0.13
Rectum (n = 70)	24.9 ± 4.2	19.7 ± 4.8	20.7 ± 3.2	18.8 ± 3.8	20.9 ± 3.8	71.9 ± 30.0	70.9 ± 29.5	83.6 ± 24.9	50.5 ± 24.1	64.5 ± 17.7	74.6 ± 31.7	89.6 ± 19.1	77.1 ± 16.1	0.81 ± 0.13
P-value	0.346	0.214	0.296	0.809	0.023^a	0.246	0.545	0.811	0.493	0.364	0.375	0.574	0.035^a	0.873
Current Treatment
Yes (n = 51)	25.9 ± 3.1	20.1 ± 4.0	21.0 ± 3.0	19.1 ± 3.9	21.8 ± 3.3	78.3 ± 30.5	76.4 ± 25.6	84.5 ± 24.0	55.6 ± 26.1	68.0 ± 16.7	82.0 ± 27.1	89.3 ± 18.0	80.0 ± 14.7	0.83 ± 0.12
No (n = 108)	23.9 ± 4.6	20.3 ± 4.7	21.0 ± 3.1	18.0 ± 4.3	21.2 ± 3.5	69.0 ± 27.9	64.8 ± 30.6	83.5 ± 27.5	45.4 ± 26.5	62.0 ± 19.7	67.5 ± 34.3	87.3 ± 23.3	80.3 ± 15.0	0.77 ± 0.14
P-value	0.003^a	0.797	0.937	0.113	0.301	0.074	0.015^a	0.819	0.026^a	0.053	0.005^a	0.564	0.922	0.010^a
Stoma
Yes (n = 21)	24.8 ± 3.1	20.2 ± 4.9	20.7 ± 3.8	17.2 ± 2.8	20.7 ± 4.4	71.3 ± 24.7	60.6 ± 27.3	75.0 ± 26.9	49.3 ± 24.3	61.3 ± 17.2	61.3 ± 31.9	89.4 ± 20.0	76.9 ± 19.6	0.77 ± 0.09
No (n = 138)	25.3 ± 3.9	20.1 ± 4.1	21.1 ± 3.0	18.9 ± 4.2	21.8 ± 3.2	75.8 ± 30.6	74.3 ± 27.5	85.6 ± 24.7	52.7 ± 27.0	66.7 ± 18.0	79.6 ± 29.5	88.5 ± 20.0	80.6 ± 13.8	0.82 ± 0.14
P-value	0.545	0.928	0.580	0.074	0.185	0.531	0.040^a	0.080	0.596	0.204	0.011^a	0.849	0.296	0.181
Vital Status
Alive (n = 145)	25.3 ± 3.8	20.4 ± 3.9	21.0 ± 3.1	18.9 ± 4.1	21.6 ± 3.4	77.4 ± 29.0	74.4 ± 27.5	84.6 ± 24.5	54.0 ± 26.0	65.8 ± 17.4	78.3 ± 29.8	88.6 ± 20.4	79.7 ± 14.7	0.82 ± 0.13
Death (n = 15)	24.5 ± 3.6	18.1 ± 6.3	20.8 ± 2.9	17.2 ± 3.6	21.9 ± 2.9	53.6 ± 30.8	53.6 ± 24.2	80.4 ± 31.3	35.0 ± 27.0	67.9 ± 22.8	66.1 ± 34.8	88.4 ± 15.1	83.9 ± 15.1	0.73 ± 0.12
P-value	0.424	0.064	0.837	0.137	0.750	0.004^a	0.007^a	0.554	0.011^a	0.685	0.152	0.970	0.306	0.019^a
CRC Recurrence^b
Yes (n = 22)	24.3 ± 5.5	20.9 ± 5.1	20.2 ± 3.7	18.8 ± 3.1	22.0 ± 3.4	67.0 ± 27.2	57.4 ± 26.9	79.5 ± 29.5	51.8 ± 25.7	65.9 ± 23.8	68.2 ± 32.9	91.5 ± 19.0	83.5 ± 19.0	0.77 ± 0.13
No (n = 115)	25.6 ± 3.4	20.2 ± 4.0	21.2 ± 2.9	18.7 ± 4.4	21.4 ± 3.5	78.5 ± 29.2	75.0 ± 27.2	85.1 ± 24.6	53.4 ± 26.2	67.0 ± 16.7	80.2 ± 29.4	88.3 ± 20.0	80.0 ± 14.2	0.82 ± 0.13
P-value	0.151	0.501	0.149	0.925	0.449	0.091	0.006^a	0.350	0.791	0.801	0.090	0.499	0.315	0.073

Note: AJCC = American Joint Committee on Cancer.
FACT-C subscales: PWB = physical well-being; SWB = social well-being; EWB = emotional well-being; FWB = functional well-being; CCS = colorectal cancer subscale;
SF-12 subscales: PF = physical functioning; RP = role physical; BP = bodily pain; GH = general health; VT = vitality; SF = social functioning; RE = role emotional; MH = mental health.
^aSignificant differences (P < 0.05) between groups by independent t-test.
^bExcluded 23 subjects who had a prior CRC recurrence before the baseline assessment.
^cHigher scores represent a higher level of functioning or a better HRQOL.

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