Skip to main content

Table 2 Hazards ratios for death in an intention-to-treat population (n = 967) based on univariable and multivariable analyses

From: Clinical implications of SPRR1A expression in diffuse large B-cell lymphomas: a prospective, observational study

 

Univariable analysis

Multivariable analysis

 

HR (95% CI)

P*

HR (95% CI)

P

Age (years)

 

0.033

 

0.421

   ≤60 y

1 (Ref)

 

1 (Ref)

 

   >60 y

1.231 (1.017–1.490)

0.033

1.112 (0.762–1.397)

0.421

Sex

 

0.816

 

0.736

   Women

1 (Ref)

 

1 (Ref)

 

   Men

1.025 (0.833–1.261)

0.816

1.103 (0.836–1.207)

0.736

Extranodal sites

 

0.576

 

0.512

   0–1 site

1 (Ref)

 

1 (Ref)

 

   More than 1 site

1.080 (0.824–1.416)

0.576

1.375 (0.831–1.454)

0.512

Performance status

 

0.058

 

0.062

   0–1

1 (Ref)

 

1 (Ref)

 

   2–4

1.755 (0.838–2.146)

0.058

1.172 (0834–1.884)

0.062

Clinical stage

 

0.000

 

0.024

   I or II

1 (Ref)

 

1 (Ref)

 

   III or IV

1.742 (1.382–3.666)

0.000

1.217 (1.114–2.371)

0.024

Bulky disease >10 cm

 

0.221

 

0.413

   No

1 (Ref)

 

1 (Ref)

 

   Yes

1.177 (0.591–1.529)

0.221

1.124 (0.734–1.349)

0.413

Evolution

 

0.789

 

0.442

   CR

1 (Ref)

 

1 (Ref)

 

   No CR

0.901 (0.723–1.122)

0.789

0.834 (0.644–1.176)

0.442

IPI Score

 

0.007

  

   0–1

1 (Ref)

   

   2

1.236 (1.074–2.537)

0.003

  

   3

1.779 (1.362–2.778)

0.014

  

   4–5

2.343 (1.742–4.621)

0.000

  

Lactate dehydrogenase

 

0.011

 

0.031

   Normal

1 (Ref)

 

1 (Ref)

 

   Elevated

1.921 (1.347–3.312)

0.011

1.383 (1.152–2.511)

0.031

SPRR1A expression

 

0.000

 

0.013

   Negative

1 (Ref)

 

1 (Ref)

 

   Positive

1.792 (1.364–3.778)

0.000

1.564 (1.337–2.464)

0.013

  1. HR, hazard ratio; CI, confidence interval; Ref, reference category; IPI, International Prognostic Index; CR, complete remission.
  2. *Derived from tests of HR for prognostic factors in the univariable model.
  3. †Cox-regression analysis, controlling for all of the prognostic factors listed in the table, except IPI Score.