Figure 4

“LP type” DLBCL, presumably transformed from NLPHL. Cervical lymph node biopsy of one of the patients presenting with “LP type” DLBCL. a. HE, 40×. The lymph node architecture is effaced with open sinuses. b. HE, 400×. Higher magnification reveals a blast infiltrate with a broad, pale cytoplasm and large numbers of histiocytes. c. Blasts stain partly positive for CD75 (400×). d. A subset of blasts is positive for J-chain (400×). e. The infiltrate weakly expresses EMA (200×). f. IgD is strongly expressed in the blast population (400×).