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Figure 6 | BMC Cancer

Figure 6

From: Tumor-associated macrophage-derived IL-6 and IL-8 enhance invasive activity of LoVo cells induced by PRL-3 in a KCNN4 channel-dependent manner

Figure 6

Immunostaining for TAMs, IL-6 and IL-8 in CRC tissues from early to late stage. A and B) Confocal microscopy for immunostaining of stages I and IV CRC tissues with CD68 antibody (green), anti-IL-6 (A, red) and anti-IL-8 (B, red). Cell nuclei were counterstained with DAPI (original magnification, ×200), (images of high resolution are in the Additional files 1 and 2). C) Quantitative analysis of number of TAMs per field. **p < 0.01, compared with stage IV. D) Kaplan–Meier survival curve of patients with colorectal cancer with lower (≤20 per view of field, n = 29) and higher IL-6 and IL-8 double positive TAMs counts (>20 per view of field, n = 42; p < 0.05).

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