Figure 11

Effects of SPM and Duopafei on metastasis burden in resected 4T1 ^luc chemotherapy animal model. (A) In vivo bioluminescent images of mice (n = 4) after treatment with 5% glucose solution (negative control), Duopafei, or SPM. (B) Metastases progression was monitored quantitatively in the Duopafei- and SPM-treated groups at day 49 after inoculation using biophotonic imaging analysis. (C) Bodyweight changes in mice treated with 5% glucose solution (negative control), Duopafei, and SPM. Significant bodyweight loss was observed in the Duopafei-treated group compared with the SPM-treated group (P < 0.05). (D) Representative histopathological images of lungs in the 5% glucose solution (negative control), Duopafei- and SPM-treated groups. (Scale bar: 20 μm).