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Table 5 Univariate and multivariate Cox regression analysis for overall survival based on Beclin-1 expression and clinicopathological variables

From: The expression of beclin-1, an autophagic gene, in hepatocellular carcinoma associated with clinical pathological and prognostic significance

Variables Univariate analysis Multivariate analysis
  Hazard ratio (95% CI) P Adjusted hazard ratio (95% CI) P
Age 0.814 (0.500-1.325) 0.407   
Sex 1.139 (0.621-2.091) 0.673   
Tumor size ( ≤ 5 cm vs. >5 cm) 2.408 (1.474-3.935) 0.000 2.532 (1.539-4.165) 0.000
Edmondson grades (I+II vs. III+IV) 1.421 (1.109-1.821) 0.005 1.365 (1.062-1.753) 0.015
TNM stage (I+II vs. III+IV) 1.566 (1.217-2.014) 0.000 1.948 (1.410-2.692) 0.000
Capsular infiltration (Negative vs. Positive) 0.555 (0.340-0.906) 0.018   0.896
Vascular invasion (Negative vs. Positive) 1.911 (1.162-3.143) 0.011   0.999
Cirrhosis background 1.586 (0.809-3.110) 0.179   
Serum AFP level 1.606 (0.961-2.683) 0.071   
HbsAg status 1.317 (0.689-2.516) 0.405   
Multinodular tumor (Single vs. Multiple) 0.998 (0.521-1.909) 0.995   
Beclin-1 [(−+) vs. (++)] 0.690 (0.492-0.967) 0.031 0.667 (0.473-0.941) 0.021