Table 5 Univariate and multivariate Cox regression analysis for overall survival based on Beclin-1 expression and clinicopathological variables
Variables | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| Â | Hazard ratio (95% CI) | P | Adjusted hazard ratio (95% CI) | P |
Age | 0.814 (0.500-1.325) | 0.407 | Â | Â |
Sex | 1.139 (0.621-2.091) | 0.673 | Â | Â |
Tumor size ( ≤ 5 cm vs. >5 cm) | 2.408 (1.474-3.935) | 0.000 | 2.532 (1.539-4.165) | 0.000 |
Edmondson grades (I+II vs. III+IV) | 1.421 (1.109-1.821) | 0.005 | 1.365 (1.062-1.753) | 0.015 |
TNM stage (I+II vs. III+IV) | 1.566 (1.217-2.014) | 0.000 | 1.948 (1.410-2.692) | 0.000 |
Capsular infiltration (Negative vs. Positive) | 0.555 (0.340-0.906) | 0.018 | Â | 0.896 |
Vascular invasion (Negative vs. Positive) | 1.911 (1.162-3.143) | 0.011 | Â | 0.999 |
Cirrhosis background | 1.586 (0.809-3.110) | 0.179 | Â | Â |
Serum AFP level | 1.606 (0.961-2.683) | 0.071 | Â | Â |
HbsAg status | 1.317 (0.689-2.516) | 0.405 | Â | Â |
Multinodular tumor (Single vs. Multiple) | 0.998 (0.521-1.909) | 0.995 | Â | Â |
Beclin-1 [(−+) vs. (++)] | 0.690 (0.492-0.967) | 0.031 | 0.667 (0.473-0.941) | 0.021 |