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Figure 6 | BMC Cancer

Figure 6

From: Quantitative analysis of castration resistant prostate cancer progression through phosphoproteome signaling

Figure 6

Response of LNCaP cells to targeted inhibitors. A) The relative cell survival of LNCaPs treated with targeted inhibitors in androgen depleted media after 72 hours. Relative survival was normalized to untreated control LNCaPs in androgen depleted media (100%). Error bars are std. dev. from mean. B) The degree to which each targeted inhibitor reduced phosphorylation of the phosphoprotein as compare to control conditions. A thicker line indicates a stronger reduction in phosphorylation. Edges in average effect over 30 minutes, 4 hours, and 24 hours. C) The degree to which each targeted inhibitor activated phosphorylation of the phosphoprotein as compare to control conditions. A thicker line indicates an increase phosphorylation. Edges in average effect over 30 minutes, 4 hours, and 24 hours. D) The effect of LY294002 treatment on p-Akt, p-GSK3, and p-RPS6. PI3K and mTor were not measured. A stronger color red indicates increased inhibition. E) The effect of Temsirolimus treatment on p-Akt, p-GSK3, and p-RPS6. PI3K and mTor were not measured. A stronger color red indicates increased inhibition.

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