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Figure 3 | BMC Cancer

Figure 3

From: Quantitative analysis of castration resistant prostate cancer progression through phosphoproteome signaling

Figure 3

Modeling the effect of androgen treatment of cell signaling. A) The percent change in phosphoprotein levels due to DHT treatment of LNCaP cells in androgen depleted media as compared to the control condition. A HSP27 phosphorylation value of 3200% was observed at the 30 minute time point. B) The relative survival of LNCaP cells under various treatment conditions in response to androgen treatment (DHT), a PI3K inhibitor (LY294002), or a combination of DHT and LY294002 in androgen depleted media as compared to the control condition of androgen depleted media. DHT is significantly greater than all other groups (** equals P-value < 0.01). Error bars are std. dev. from mean. Values are normalized to the untreated control condition’s mean. C)A diagrammatic overview of the proposed signaling interactions between the androgen receptor, PI3K signaling pathway, RPS6, and cell cycle targets.

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