RNA-binding protein RNPC1: acting as a tumor suppressor in breast cancer

BMC Cancer

Table 2 The association between RNPC1 protein expression and clinicopathologic features in breast cancer

Clinicopathologic parameters	Number of case	RNPC1	RNPC1	p-value
		Low expression	High expression
Age (years)
≤55	68	46	22	0.631
>55	53	38	15
Tumor Size (cm)
≤2	38	25	13	0.557
>2	83	59	24
TNM stage
I	24	15	9	0.411
II + III	97	69	28
Lymph node metastasis
≤3	96	62	34	0.024
>3	25	22	3
Grade
I	7	4	3	0.215
II	67	51	16
III	30	20	10
unclear	17	9	8
ER status
Negative	40	24	16	0.181
Positive	70	53	17
unclear	11	7	4
PR status
Negative	58	46	12	0.023
Positive	63	38	25
Her2 status
Negative	81	61	20	0.117
Positive	32	18	14
suspect	8	5	3
Ki67
≤15%	43	30	13	0.402
>15%	52	32	20
CK5/6
Negative	46	29	17	0.800
Positive	15	10	5
P53
Negative	42	32	10	0.039
Positive	52	29	23
PCNA
Negative	2	2	0	0.619
+	36	27	9
++	22	16	6
+++	12	7	5
Histology
ductal	106	75	31	0.397
special	15	9	6

ER: oestrogen receptor; PR: progesterone receptor; HER2: human epidermal growth factor receptor 2.
TNM classification according to the Union Internationale Contre le Cancer criteria. HER2 positivity 3+ in immunohistochemistry or positive fluorescent in situ hybridisation test.

ISSN: 1471-2407