| |
Men
|
Women
|
|---|
| |
Cases n = 1,336
|
Person-years
|
HR
|
95% CI
|
Cases n = 840
|
Person-years
|
HR
|
95% CI
|
|---|
|
Smoking status
| | | | | | | | |
|
Never
|
298/98,388
|
1,369,691
|
1.00
|
Ref.
|
350/123,503
|
1,744,944
|
1.00
|
Ref.
|
|
Former
|
433/78,662
|
1,138,881
|
1.28
|
1.11-1.50
|
169/64,021
|
824,913
|
1.26
|
1.05-1.52
|
|
Current
|
605/122,326
|
1,913,477
|
1.26
|
1.09-1.45
|
321/115,342
|
1,621,343
|
1.29
|
1.10-1.51
|
|
Ptrend
b
| | | |
<0.05
| | | |
<0.05
|
|
Ever
|
1,038/200,988
|
3,052,358
|
1.27
|
1.11-1.45
|
490/179,363
|
2,446,256
|
1.28
|
1.11-1.48
|
|
Ever smokersc
| | | | | | | | |
|
Age at smoking initiation in years
| | | | | | | | |
|
≥25
|
116/16,415
|
268,600
|
1.23
|
0.99-1.52
|
99/23,150
|
357,101
|
1.19
|
0.95-1.49
|
|
20-24
|
211/38,540
|
592,480
|
1.35
|
1.13-1.61
|
136/40,824
|
588,736
|
1.45
|
1.18-1.78
|
|
≤19
|
362/96,856
|
1,294,339
|
1.28
|
1.08 − 1.50
|
142/80,620
|
928,955
|
1.35
|
1.10-1.67
|
|
Ptrend
b
| | | |
<0.05
| | | |
<0.05
|
|
Number of cigarettes smoked per day
| | | | | | | | |
|
1-9
|
207/39,218
|
604,421
|
1.07
|
0.90-1.29
|
169/59,570
|
824,198
|
1.15
|
0.96-1.39
|
|
10-19
|
524/99,761
|
1,526,804
|
1.35
|
1.17-1.56
|
255/93,002
|
1,268,980
|
1.37
|
1.16-1.62
|
|
≥20
|
259/56,319
|
832,845
|
1.31
|
1.11-1.55
|
64/25,270
|
337,874
|
1.38
|
1.05-1.81
|
|
Ptrend
b
| | | |
<0.0001
| | | |
<0.0001
|
|
Smoking duration in years
| | | | | | | | |
|
1-19
|
326/80,190
|
1,250,222
|
1.21
|
1.03-1.42
|
220/87,999
|
1,263,528
|
1.17
|
0.99 − 1.40
|
|
20-29
|
457/97,685
|
1,471,526
|
1.29
|
1.11-1.50
|
222/81,713
|
1,089,772
|
1.37
|
1.15-1.64
|
|
≥30
|
232/21,144
|
299,518
|
1.31
|
1.09-1.59
|
48/7,918
|
76,398
|
1.54
|
1.11-2.12
|
|
Ptrend
b
| | | |
<0.05
| | | |
<0.0001
|
|
Number of pack-years smokedd
| | | | | | | | |
|
0-9
|
298/68,003
|
943,796
|
1.17
|
0.99-1.37
|
241/88,884
|
1,270,193
|
1.21
|
1.02-1.42
|
|
10-19
|
385/74,235
|
1,014,305
|
1.33
|
1.14-1.54
|
178/64,544
|
862,029
|
1.38
|
1.14-1.66
|
|
≥20
|
302/52,392
|
647,100
|
1.35
|
1.14-1.58
|
69/23,263
|
288,147
|
1.47
|
1.13-1.91
|
|
Ptrend
b
| | | |
<0.0001
| | | |
<0.0001
|
-
aAdjusted for age, body mass index, level of physical activity all at enrollment and duration of education. bNever smokers included in the model. cTotal numbers of ever smokers do not equal the total in different smoking exposures due to missing values in different smoking exposures groups. dPack-years were calculated as numbers of cigarettes smoked per day, divided by 20 and multiplied by the number of years smoked.
