TY - JOUR AU - Abubaker, Khalid AU - Luwor, Rodney B. AU - Zhu, Hongjian AU - McNally, Orla AU - Quinn, Michael A. AU - Burns, Christopher J. AU - Thompson, Erik W. AU - Findlay, Jock K. AU - Ahmed, Nuzhat PY - 2014 DA - 2014/05/06 TI - Inhibition of the JAK2/STAT3 pathway in ovarian cancer results in the loss of cancer stem cell-like characteristics and a reduced tumor burden JO - BMC Cancer SP - 317 VL - 14 IS - 1 AB - Current treatment of ovarian cancer patients with chemotherapy leaves behind a residual tumor which results in recurrent ovarian cancer within a short time frame. We have previously demonstrated that a single short-term treatment of ovarian cancer cells with chemotherapy in vitro resulted in a cancer stem cell (CSC)-like enriched residual population which generated significantly greater tumor burden compared to the tumor burden generated by control untreated cells. In this report we looked at the mechanisms of the enrichment of CSC-like residual cells in response to paclitaxel treatment. SN - 1471-2407 UR - https://doi.org/10.1186/1471-2407-14-317 DO - 10.1186/1471-2407-14-317 ID - Abubaker2014 ER -