Figure 3
Decreased platinum-DNA adduct formation in cisplatin-metformin treated OSCC cells. OSCC cells were treated with LD30 concentrations of cisplatin, either alone or in combination with 10 mM metformin. Genomic DNA was extracted and platinum quantified by ICP-MS which showed a decrease in platinum in cisplatin-metformin treated cells in comparison to cells treated with cisplatin alone (values expressed per μg of DNA) (n = 3, mean ± SD).