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Figure 1 | BMC Cancer

Figure 1

From: Metformin induces an intracellular reductive state that protects oesophageal squamous cell carcinoma cells against cisplatin but not copper-bis(thiosemicarbazones)

Figure 1

Anti-proliferative effects of metformin on OSCC cells. A, Cells exposed to 10 mM metformin for 24 hours showed a decrease in cell number in comparison to untreated controls across all cell lines, n = 4, mean ± SD. B, Quantification and C,representative figures of flow cytometry analysis (from SNO cells) for untreated cells (Untreated), FCS deprived control (FCS Control) and cells exposed to 10 mM metformin for 24 hours (Metformin). Metformin treated cells exhibited an accumulation at the G0/G1 stage of the cell cycle across all cell lines, expressed as % of cells in phase of cell cycle (n = 3, mean ± SD), where for all cells there was a statistically significant increase in cells in G0/G1 in metformin treated cells relative to untreated controls with WHCO1 p = 0.05, WHCO5 p = 0.04 and SNO p = 0.01.

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