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Table 2 Univariate analysis of perineural invasion and clinicopathologic variables in patients with primary esophageal squamous cell carcinoma (log-rank test)

From: The prognostic effect of perineural invasion in esophageal squamous cell carcinoma

Variables

Cases

Mean survival (months)

Median survival (months)

P value

Age (years)

   

0.657

  ≤ 57.0†

230

62.5

42.0

 

  > 57.0

203

60.1

58.0

 

Gender

   

0.016

  Female

112

72.6

NR

 

  Male

321

57.7

41.0

 

Location

   

0.083

  Upper

28

68.5

79.0

 

  Middle

298

56.2

41.0

 

  Lower

107

70.7

63.0

 

Tumor size (cm)

   

0.076

  ≤ 4‡

277

66.1

63.0

 

  > 4

156

54.3

38.0

 

Differentiation

   

0.021

  Well

67

61.9

64.0

 

  Moderate

288

65.5

64.0

 

  Poor

78

44.4

26.0

 

pT status

   

0.002

  T1

20

58.2

NR

 

  T2

104

71.2

74.0

 

  T3

309

57.9

38.0

 

pN status

   

< 0.0001

  N0

233

79.3

NR

 

  N1

111

48.2

40.0

 

  N2

71

27.4

16.0

 

  N3

18

19.1

11.0

 

Stage

   

< 0.0001

  I

25

67.6

NR

 

  II

238

76.4

NR

 

  III

170

34.9

22.0

 

Perineural invasion

   

< 0.0001

  Absent

224

71.4

79.0

 

  Present

209

47.7

27.0

 
  1. †Median age; ‡Median size; NR indicates not reached.