Table 2 Key features of patient-reported outcome (PRO) scales used in the SystHERs registry
PRO instrument | Key features | Frequency of administration |
|---|---|---|
Overall Health Related Quality of Life (HRQOL) question | Single question: “On a scale of 0–100, how would you rate your quality of life today?” | Every 90 days |
Functional Assessment of Cancer Therapy-Breast (FACT-B) [29] | Self-report instrument designed to measure multidimensional QOL in patients with breast cancer | Every 90 days |
Alopecia patient assessment | For use only in patients with alopecia; developed by Genentech | Every 90 days |
Patient Neurotoxicity Questionnaire (PNQ) [30] | Assesses neurosensory and neuromotor symptoms on activities of daily living | Every 90 days |
MD Anderson Symptom Inventory Brain Tumor Module (MDASI-BT) [31] | Only items related to cognitive functioning and interference with daily functioning will be administered | Every 90 days |
Rotterdam Symptom Checklist [32] | Self-report instrument to measure QOL in cancer patients. Only items related to activities of daily living will be administered | Every 90 days |
Work Productivity and Activity Impairment-Specific Health Problem (WPAI-SPH) questionnaire [33] | Patient-reported quantitative assessment of the amount of absenteeism, presenteeism, and daily activity impairment attributable to a specific health problem (breast cancer); unemployed patients will answer only 2 questions | Every 90 days |
Health Care Survey | Quantifies hospitalizations, emergency room visits, and out-of-pocket expenses; developed by Genentech | Every 90 days |