Down-regulation of sirtuin 3 is associated with poor prognosis in hepatocellular carcinoma after resection

BMC Cancer

Table 3 Survival analysis of Sirt3 expression in HCC patients when stratified by clinicopathologic factors

Variables		iSirt3-TTR	iSirt3-OS	pSirt3-TTR	pSirt3-OS
		P value	P value	P value	P value
TNM
I	154	0.110	0.059	0.078	0.100
II/III	188	0.066	0.004	0.020	0.031
BCLC
A	233	0.008	< 0.001	0.020	0.278
B/C	109	0.690	0.366	0.204	0.020
HBV infection
No	94	0.037	0.127	0.343	0.217
Yes	248	0.095	0.003	0.033	0.051
Cirrhosis
No	303	0.029	0.003	0.046	0.059
Yes	38	0.151	0.076	0.131	0.148
AFP
≤20	132	0.075	0.078	0.371	0.334
>20	210	0.104	0.006	0.049	0.079
γ-GT (U/L)
≤54	163	0.639	0.208	0.025	0.111
>54	179	0.012	0.002	0.384	0.164
Tumor size
≤5	229	0.127	0.045	0.094	0.093
>5	113	0.046	0.003	0.062	0.108
Tumor number
1	297	0.011	< 0.001	0.016	0.023
≥2	44	0.547	0.903	0.566	0.585
Tumor thrombi
No	249	0.008	0.002	0.015	0.263
Yes	93	0.706	0.154	0.386	0.024
Tumor capsule
Yes	183	0.036	0.002	0.200	0.191
No	159	0.209	0.124	0.035	0.064
Differentiation
Well	255	0.007	< 0.001	0.009	0.028
Poor	87	0.856	0.879	0.838	0.535

Note: χ2 tests for all the analysis. AFP, alpha-fetoprotein, γ-GT, γ-glutamyl transferase. OS, overall survival; TTR, time to recurrence.

ISSN: 1471-2407