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Table 3 Cell death biological function category showing a significant fold change in genes belonging to HPMCs exposed to malignant ascites compared to benign fluids (Fold change > 2, P < 0.05)

From: Role of malignant ascites on human mesothelial cells and their gene expression profiles

Symbol

Description

Fold change

BDKRB1

Bradykinin receptor B1

-2.18

IL-8

Interleukin 8

-3.38

SOX17

SRY-box 17

-3.33

BMP2

Bone morphogenetic protein 2

-2.58

NR4A3

Nuclear receptor subfamily 4, group A, member 3

-2.30

RASD1

RAS, dexamethasone-induced 1

-2.27

PHLDA1

Pleckstrin homology-like domain, member 1

-3.40

TRIB3

Tribbles homolog 3

-2.22

HBEGF

Heparin-binding EFG-like growth factor

-2.20

SPRY2

Sprouty homolog 2

-2.03

AREG

Amphiregulin

3.52

DDX58

DEAD box polypeptide 58

2.37

DEPDC1

DEP domain containing 1

7.06

IRS2

Insulin receptor substrate 2

2.11

SMAD5

SMAD, family member 5

2.10

MT1A

Metallothionein 1A

2.10

MAP4K4

Mitogen-activated protein kinase kinase kinase kinase 4

2.04