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Figure 1 | BMC Cancer

Figure 1

From: RETRACTED ARTICLE: STMN-1 is a potential marker of lymph node metastasis in distal esophageal adenocarcinomas and silencing its expression can reverse malignant phenotype of tumor cells

Figure 1

STMN1 expression in the distal esophageal adenocarcinoma tissue samples and cell lines. (A) Distal esophageal adenocarcinoma tissue samples were lysed and immunoblotting was performed to detect expression of STMN1. Actin was used as loading control. STMN1 expression was low or negative in the samples obtained from the patients without lymph node metastasis (pN0) and pT1 classification but in the patients with lymph node metastasis (pN+) status STMN1 was highly Overexpressed, some pT4a stage patients also showed moderate STMN1 expression. (B) Light microscopic immunocytochemistry revealed an intense cytoplasmic presence of STMN1 protein in esophageal cancer cells. (C) Image at High-resolution showed strong cytoplasmic expression of STMN1. (D) Fluorescence microscopy of DAPI stained cells. (E) Immunofluorescent images of distal esophageal adenocarcinoma cells labeled with an antibody against STMN1, the staining was repeated in triplicate three independent times.

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