Figure 7

Genomic location of wild-type and mutated GATA3 transcription factor in T47D and MCF7 cell lines. A) Number of GATA3 ChIP-seq peaks in T47D and MCF7 cells. B) GATA3 peak distribution relative to distance from the closest transcription start site (TSS) in T47D and MCF7 cells. C) GATA3 ChIP-seq peak distribution within 10 kb from the closest TSS in T47D and MCF7 cells. D) GATA3 ChIP-seq peak distribution within 100 kb from the closest TSS in T47D and MCF7 cells. E) GATA3 occupancy enriched regions sorted by increasing ChIP-seq signal. Peaks were divided into peaks not associated with a TSS (no TSS) and peaks within 1 kb or 10 kb from the closest TSS (TSS in 1 or 10 kb). y-axis is scaled to % of maximal for given cell line RPKM (reads per kilobase per million). F) ChIP-seq signal range in T47D and MCF7 cells. Box represents 25% to 75% of the range and whiskers are 5% to 95%. Black dot is median and yellow dot is mean value. Legend - see E).