Ingenuity Pathway Analysis of genes positively regulated by unliganded GR. IPA identified this hub as a top signaling network among candidate genes downregulated in EPH-4 shGR-19 compared to EV-50 (IPA network score = 41) i.e. positively regulated by GR. This network was associated with dermatological diseases and conditions, inflammatory disease, and neurological disease. Annotation of IPA network shapes and molecular relationships as specified in Figure 3.