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Figure 2 | BMC Cancer

Figure 2

From: Expression microarray identifies the unliganded glucocorticoid receptor as a regulator of gene expression in mammary epithelial cells

Figure 2

BRCA1 promoter activity is reduced and no longer repressed in the presence of HC in cells stably expressing shGR. EPH-4 EV-50 and shGR-19 stable cells were transiently transfected with the L6 BRCA1 promoter reporter construct, treated 24 hours after transfection with either ethanol vehicle (-HC) or 1 μg/mL HC (+HC), and assayed for luciferase activity following a 48 hour incubation. Bars represent the mean of technical replicates, and error bars represent standard deviation (N = 3). Statistically significant changes in BRCA1 promoter activity relative to EV-50 (-HC) are indicated: one asterisk, p < 0.05 (significant); two asterisks, p < 0.005 (very significant).

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