Figure 1From: Knocking down CDK4 mediates the elevation of let-7c suppressing cell growth in nasopharyngeal carcinoma Stably knocking down CDK4 expression suppresses cell proliferation and cell cycle progression in vitro in NPC. A. CDK4 protein expression was stably suppressed by lentivirus-mediated shRNA in NPC cells. B. In vitro viability of NPC cells was decreased in CDK4-suppressed cells compared to PLV-Ctr cells by MTT assay. C. In vitro proliferative ability of NPC cells was significantly decreased in CDK4-suppressed cells compared to PLV-Ctr cells by colony formation assay. D. Stably downregulated CDK4 expression blocked cell cycle transition from G1 to S in shRNA-CDK4-2 and 3 cells. Data are presented as mean ± SD for three independent experiments (*p < 0.05).Back to article page