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Figure 5 | BMC Cancer

Figure 5

From: Inhibition of autophagy enhances the cytotoxic effect of PA-MSHA in breast cancer

Figure 5

Protective effect of PA-MSHA on tumor growth in vivo. A. Tumor volume measured at the indicated time after MDA-MB-231HM -shIRE1, MDA-MB-231HM-shCON cells were implanted into the mammary fat pad of mice. *P < 0.01 B. Body weight of mice measured at the indicated time after MDA-MB- 231HM-shIRE1, MDA-MB-231HM-shCON cells were implanted into the mammary fat pad of mice. C. Apoptosis was measured by TUNEL staining of tumor tissue sections. Tissues were counterstained with DAPI to detect cell nuclei. D &E. The expression of IRE1-a, cleaved-caspase 3, LC3 in PA-MSHA-treated xenografts (D). The relative expression of IRE1-a, cleaved-caspase3 and LC3-II/LC3-I of each sample.

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