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Table 4 Standardised incidence ratios of second primary cancers at >60 days - 5 years

From: Second primary cancer risk - the impact of applying different definitions of multiple primaries: results from a retrospective population-based cancer registry study

 

Registry

IARC/IACR rules

SEER rules

Registry‡

First primary cancer

Number with second cancer

SIR (95% CI)

Number with second cancer

SIR (95% CI)

Number with second cancer

SIR (95% CI)

Number with second cancer

SIR‡ (95% CI)

Lung (C33-34)

119

0.79

(0.65, 0.94)

105

0.69

(0.57, 0.84)

112

0.74

(0.61, 0.89)

98

0.83

(0.67, 1.01)

Colorectal (C18-20)

324

0.89

(0.80, 1.00)

301

0.83

(0.74, 0.93)

323

0.89

(0.80, 1.00)

271

0.86

(0.76, 0.97)

Female breast (C50)

363

0.96

(0.86, 1.06)

272

0.71

(0.63, 0.80)

348

0.92

(0.82, 1.02)

274

0.96

(0.85, 1.08)

 Age <50

52

2.13

(1.58, 2.78)

25

1.02

(0.65, 1.50)

49

2.00

(1.48, 2.64)

28

1.67

(1.11, 2.42)

 Age ≥50

311

0.88

(0.78, 0.98)

247

0.69

(0.61, 0.78)

299

0.84

(0.75, 0.94)

246

0.92

(0.81, 1.04)

Prostate (C61)

342

0.71

(0.63, 0.79)

339

0.70

(0.63, 0.78)

323

0.89

(0.80, 1.00)

339

0.88

(0.79, 0.98)

Head & neck (C00-C14, C30-C32)

204

1.93

(1.67, 2.21)

196

1.85

(1.60, 2.13)

201

1.90

(1.64, 2.18)

176

1.74

(1.49, 2.02)

Stomach (C16)

46

1.05

(0.77, 1.40)

43

0.98

(0.71, 1.32)

44

1.00

(0.73, 1.35)

43

1.02

(0.74, 1.38)

Bladder (C67)

140

1.41

(1.19, 1.67)

138

1.39

(1.10, 1.55)

140

1.41

(1.19, 1.67)

139

1.46

(1.23, 1.73)

Oesophagus (C15)

26

0.80

(0.52, 1.17)

25

0.77

(0.50, 1.13)

25

0.77

(0.50, 1.13)

25

0.80

(0.51, 1.18)

Melanoma (C43)

102

1.35

(1.10, 1.64)

75

0.98

(0.77, 1.23)

102

1.35

(1.10, 1.64)

75

1.01

(0.79, 1.27)

Ovarian (C56)

19

0.61

(0.36, 0.95)

18

0.58

(0.34, 0.91)

19

0.61

(0.37, 0.95)

18

0.60

(0.36, 0.95)

All of above

1685

0.96

(0.91, 1.00)

1512

0.86

(0.81, 0.90)

1637

1.00

(0.95, 1.05)

1458

0.99

(0.94, 1.04)

  1. ‡excluding same site.
  2. Abbreviations: SEER Surveillance Epidemiology and End Results, IARC International Agency for Research on Cancer, IACR International Association of Cancer Registries, SIR standardised incidence ratio, CI confidence interval.