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Figure 6 | BMC Cancer

Figure 6

From: Triptolide induces apoptotic cell death of human cholangiocarcinoma cells through inhibition of myeloid cell leukemia-1

Figure 6

Triptolide inhibited CCA cell growth in vivo . HuCCT1 cells were injected subcutaneously into the left flanks of athymic nude mice. When tumors reached a size of approximately 150 mm3, mice were i.p. with triptolide (0.2 mg/kg) or vehicle control every day for a total of 22 days. (A) Tumor volume was measured every three days using calipers and calculated as described in Materials and Methods (n = 5). (B) The mouse weight was measured every three days to monitor the drug effects. (C) At the end of the study, the excised tumors from each group were weighed. (D) Resected tumors from each group were photographed. (E) H & E and Ki67 staining in the tumor tissues of triptolide and vehicle treated mice (original magnification, ×200). Arrows show the Ki67 expression in tumor tissue. *p < 0.05, **p < 0.01, compared with control.

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