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Table 2 Incidence and histopathological description of malignant and benign tumors induced by DMBA

From: Activation of Akt1 accelerates carcinogen-induced tumorigenesis in mammary gland of virgin and post-lactating transgenic mice

 

^WT (N = 28) N (%)*

^^Myr-Akt1 + (N = 28) N (%)*

Infiltrating poorly differentiated mammary carcinoma with bone metastases

0

2 (7.1%)

Poorly differentiated mammary carcinoma with necrosis

2 (7.1%)

7 (25.0%)

Salivary gland carcinoma with bone metastasis

1 (3.6%)

0

Carcinoma in the wall of the stomach

1 (3.6%)

1 (3.6%)

Carcinoid pattern of malignancy in lung

1 (3.6%)

0

Benign lesions of mammary gland with lymploid tissue

0

3 (10.7%)

Endometrial cystic changes with focal hyperplasia

1 (3.6%)

0

Benign squamous epithelium tumor

1 (3.6%)

1 (3.6%)

  1. ^Wild-type mice.
  2. ^^MMTV-myr-Akt1 transgenic mice.
  3. *The percentages correspond to the total number of treated mice.