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Table 2 Incidence and histopathological description of malignant and benign tumors induced by DMBA

From: Activation of Akt1 accelerates carcinogen-induced tumorigenesis in mammary gland of virgin and post-lactating transgenic mice

  ^WT (N = 28) N (%)* ^^Myr-Akt1 + (N = 28) N (%)*
Infiltrating poorly differentiated mammary carcinoma with bone metastases 0 2 (7.1%)
Poorly differentiated mammary carcinoma with necrosis 2 (7.1%) 7 (25.0%)
Salivary gland carcinoma with bone metastasis 1 (3.6%) 0
Carcinoma in the wall of the stomach 1 (3.6%) 1 (3.6%)
Carcinoid pattern of malignancy in lung 1 (3.6%) 0
Benign lesions of mammary gland with lymploid tissue 0 3 (10.7%)
Endometrial cystic changes with focal hyperplasia 1 (3.6%) 0
Benign squamous epithelium tumor 1 (3.6%) 1 (3.6%)
  1. ^Wild-type mice.
  2. ^^MMTV-myr-Akt1 transgenic mice.
  3. *The percentages correspond to the total number of treated mice.