Figure 1

Chronological changes on magnetic resonance imaging (MRI) document the tumor recurrence and response. Coronal MRI T1-weighted images with gadolinium-based contrast were taken at the following times: (A) diagnosis, (B) post-operatively, (C) after completion of radiation therapy, (D) while receiving adjuvant chemotherapy, (E) at completion of therapy, (F) 4 months after completion of therapy, (G) upon start of vemurafenib therapy at relapse, (H) after 2 months of vemurafenib therapy, and (I) after 4 months of vemurafenib therapy.