Figure 6

Prognostic value of gene expression in primary mammary tumors related to STAT1 and leukocyte infiltration. mRNA expression levels of STAT1, STAT1 target genes, genes expressed in lymphocytes and macrophages, as well as STAT1 Y701 phosphorylation and STAT1 IHC scores were used to categorize patients into two groups with the median as discriminator. Hazard ratios for overall survival (OS) and relapse-free survival (RFS) were evaluated by Cox regression for patients with high vs. low expression and are shown as mean together with the 95% confidence interval. (A) Cohort A, all patients (n = 96) and the subset of ER-positive patients (n = 67) were evaluated; (B) Cohort B (n = 36). (C) Cohort A, all patients (n = 96), multivariate Cox regression analysis for patients with high vs. low STAT1 mRNA expression adjusted to expression of genes found to be significantly linked to bad prognosis in the evaluation of Panel A. Number of tumor samples with available data for expression analysis for the different genes in the two different cohorts are shown in Additional file 1.