Table 6 Univariate associations of HSCORE for NILCO and targets with Ki67 and p53
From: NILCO biomarkers in breast cancer from Chinese patients
Ki67 | p53 | |||||
|---|---|---|---|---|---|---|
Antigen | Negative (n=52) | Positive (n=15) | P-value* | Negative (n=40) | Positive (n=27) | P-value* |
Notch1 | 2.27(1.68-2.86) | 2.69 (2.06-3.32) | 0.010 | 2.51(1.82-3.20) | 2.63 (2.13-3.13) | 0.528 |
Negative | 1 (4.35) | 0 (0) | 0.343 | 1 (2.04) | 0 (0) | 1.000 |
Positive | 22 (95.65) | 44 (100) | 48 (97.96) | 18 (100) | ||
Notch4 | 1.42 (1–2.82) | 1.69 (1–3.48) | 0.125 | 1.51 (1–3.48) | 1.8 (1–2.87) | 0.404 |
Negative | 7 (33.33) | 8 (19.05) | 0.209 | 12 (26.67) | 3 (16.67) | 0.522 |
Positive | 14 (66.67) | 34 (80.95) | 33 (73.33) | 15 (83.33) | ||
JAG1 | 1.37 (1–2.24) | 1.21 (1–3) | 0.350 | 1.2 (1–3) | 1.54 (1–2.43) | 0.587 |
Negative | 3 (13.04) | 16 (36.36) | 0.044 | 14 (28.57) | 5 (27.78) | 0.949 |
Positive | 20 (86.96) | 28 (63.64) | 35 (71.43) | 13 (72.22) | ||
DLL4 | 3.21 (1.91 - 3.66) | 3.11 (1.19 - 3.87) | 0.584 | 3.15 (1.19 - 3.66) | 3.21 (2.59 - 3.87) | 0.651 |
Negative | NA | NA | NA | NA | NA | NA |
Positive | 23 (100) | 44 (100) | 49 (100) | 18 (100) | ||
Leptin | 3.34 (1–4) | 2.66 (1–4) | 0.841 | 2.64 (1–4) | 3.29 (1–4) | 0.541 |
Negative | 7 (30.43) | 14 (31.82) | 0.908 | 16 (32.65) | 5 (27.78) | 0.703 |
Positive | 16 (69.57) | 30 (68.18) | 33 (67.35) | 13 (72.22) | ||
OB-R | 1.08 (1–2.27) | 1.07 (1–2.3) | 0.648 | 1.08 (1–2.3) | 1.11 (1–2.2) | 0.666 |
Negative | 7 (30.43) | 15 (34.09) | 0.762 | 17 (34.69) | 5 (27.78) | 0.593 |
Positive | 16 (69.57) | 29 (65.91) | 32 (65.31) | 13 (72.22) | ||
IL-1R tI | 3.63 (1–4) | 3.63 (1.56 - 4) | 0.714 | 3.65 (1–4) | 3.55 (2.62 - 4) | 0.847 |
Negative | 1(4.35) | 0 (0) | 0.343 | 1 (2.04) | 0 (0) | 1.000 |
Positive | 22(95.65) | 44(100) | 48(97.96) | 18(100) | ||
VEGF | 4(1.04 - 4) | 3.56(2.22 - 4) | 0.056 | 2.51(± 0.69) | 2.63(± 0.5) | 0.528 |
Negative | NA | NA | NA | 1(2.04) | 0(0) | 1.000 |
Positive | 23(100) | 44(100) | 48(97.96) | 18(100) | ||
VEGFR2 | 1.09(1–2) | 1(1–2) | 0.047 | 1.51(1–3.48) | 1.8(1–2.87) | 0.404 |
Negative | 11(47.83) | 33(75) | 0.026 | 12(26.67) | 3(16.67) | 0.522 |
Positive | 12(52.17) | 11(25) | 33(73.33) | 15 (83.33) | ||