TY - JOUR AU - Jemal, A. AU - Bray, F. AU - Center, M. M. AU - Ferlay, J. AU - Ward, E. AU - Forman, D. PY - 2011 DA - 2011// TI - Global cancer statistics JO - CA Cancer J Clin VL - 61 UR - https://doi.org/10.3322/caac.20107 DO - 10.3322/caac.20107 ID - Jemal2011 ER - TY - JOUR AU - Bosch, F. X. AU - Ribes, J. AU - Cleries, R. AU - Diaz, M. PY - 2005 DA - 2005// TI - Epidemiology of hepatocellular carcinoma JO - Clin Liver Dis VL - 9 UR - https://doi.org/10.1016/j.cld.2004.12.009 DO - 10.1016/j.cld.2004.12.009 ID - Bosch2005 ER - TY - JOUR AU - Bosch, F. X. AU - Ribes, J. AU - Diaz, M. AU - Cleries, R. PY - 2004 DA - 2004// TI - Primary liver cancer: worldwide incidence and trends JO - Gastroenterology VL - 127 UR - https://doi.org/10.1053/j.gastro.2004.09.011 DO - 10.1053/j.gastro.2004.09.011 ID - Bosch2004 ER - TY - JOUR AU - Ascha, M. S. AU - Hanouneh, I. A. AU - Lopez, R. AU - Tamimi, T. A. AU - Feldstein, A. F. AU - Zein, N. N. PY - 2010 DA - 2010// TI - The incidence and risk factors of hepatocellular carcinoma in patients with nonalcoholic steatohepatitis JO - Hepatology VL - 51 UR - https://doi.org/10.1002/hep.23527 DO - 10.1002/hep.23527 ID - Ascha2010 ER - TY - JOUR AU - Farazi, P. A. AU - DePinho, R. A. PY - 2006 DA - 2006// TI - Hepatocellular carcinoma pathogenesis: from genes to environment JO - Nat Rev Cancer VL - 6 UR - https://doi.org/10.1038/nrc1934 DO - 10.1038/nrc1934 ID - Farazi2006 ER - TY - JOUR AU - Nordenstedt, H. AU - White, D. L. AU - El-Serag, H. B. PY - 2010 DA - 2010// TI - The changing pattern of epidemiology in hepatocellular carcinoma JO - Dig Liver Dis VL - 42 UR - https://doi.org/10.1016/S1590-8658(10)60507-5 DO - 10.1016/S1590-8658(10)60507-5 ID - Nordenstedt2010 ER - TY - JOUR AU - Grundy, S. M. PY - 2008 DA - 2008// TI - Metabolic syndrome pandemic JO - Arterioscler Thromb Vasc Biol VL - 28 UR - https://doi.org/10.1161/ATVBAHA.107.151092 DO - 10.1161/ATVBAHA.107.151092 ID - Grundy2008 ER - TY - JOUR AU - Nguyen, D. M. AU - El-Serag, H. B. PY - 2010 DA - 2010// TI - The epidemiology of obesity JO - Gastroenterol Clin North Am VL - 39 UR - https://doi.org/10.1016/j.gtc.2009.12.014 DO - 10.1016/j.gtc.2009.12.014 ID - Nguyen2010 ER - TY - JOUR AU - Siegel, A. B. AU - Zhu, A. X. PY - 2009 DA - 2009// TI - Metabolic syndrome and hepatocellular carcinoma: two growing epidemics with a potential link JO - Cancer VL - 115 UR - https://doi.org/10.1002/cncr.24687 DO - 10.1002/cncr.24687 ID - Siegel2009 ER - TY - JOUR AU - Whittaker, S. AU - Marais, R. AU - Zhu, A. X. PY - 2010 DA - 2010// TI - The role of signaling pathways in the development and treatment of hepatocellular carcinoma JO - Oncogene VL - 29 UR - https://doi.org/10.1038/onc.2010.236 DO - 10.1038/onc.2010.236 ID - Whittaker2010 ER - TY - JOUR AU - Massaro, M. AU - Zampolli, A. AU - Scoditti, E. AU - Carluccio, M. A. AU - Storelli, C. AU - Distante, A. AU - De Caterina, R. PY - 2010 DA - 2010// TI - Statins inhibit cyclooxygenase-2 and matrix metalloproteinase-9 in human endothelial cells: anti-angiogenic actions possibly contributing to plaque stability JO - Cardiovasc Res VL - 86 UR - https://doi.org/10.1093/cvr/cvp375 DO - 10.1093/cvr/cvp375 ID - Massaro2010 ER - TY - JOUR AU - Wasko, B. M. AU - Dudakovic, A. AU - Hohl, R. J. PY - 2011 DA - 2011// TI - Bisphosphonates induce autophagy by depleting geranylgeranyl diphosphate JO - J Pharmacol Exp Ther VL - 337 UR - https://doi.org/10.1124/jpet.110.175521 DO - 10.1124/jpet.110.175521 ID - Wasko2011 ER - TY - JOUR AU - Dudakovic, A. AU - Tong, H. AU - Hohl, R. J. PY - 2011 DA - 2011// TI - Geranylgeranyl diphosphate depletion inhibits breast cancer cell migration JO - Invest New Drugs VL - 29 UR - https://doi.org/10.1007/s10637-010-9446-y DO - 10.1007/s10637-010-9446-y ID - Dudakovic2011 ER - TY - JOUR AU - Goldstein, J. L. AU - Brown, M. S. PY - 1990 DA - 1990// TI - Regulation of the mevalonate pathway JO - Nature VL - 343 UR - https://doi.org/10.1038/343425a0 DO - 10.1038/343425a0 ID - Goldstein1990 ER - TY - JOUR AU - Vicent, D. AU - Maratos-Flier, E. AU - Kahn, C. R. PY - 2000 DA - 2000// TI - The branch point enzyme of the mevalonate pathway for protein prenylation is overexpressed in the ob/ob mouse and induced by adipogenesis JO - Mol Cell Biol VL - 20 UR - https://doi.org/10.1128/MCB.20.6.2158-2166.2000 DO - 10.1128/MCB.20.6.2158-2166.2000 ID - Vicent2000 ER - TY - JOUR AU - Shen, N. AU - Gong, T. AU - Wang, J. D. AU - Meng, F. L. AU - Qiao, L. AU - Yang, R. L. AU - Xue, B. AU - Pan, F. Y. AU - Zhou, X. J. AU - Chen, H. Q. AU - Ning, W. AU - Li, C. J. PY - 2011 DA - 2011// TI - Cigarette smoke-induced pulmonary inflammatory responses are mediated by EGR-1/GGPPS/MAPK signaling JO - Am J Pathol VL - 178 UR - https://doi.org/10.1016/j.ajpath.2010.11.016 DO - 10.1016/j.ajpath.2010.11.016 ID - Shen2011 ER - TY - JOUR AU - Shen, N. AU - Shao, Y. AU - Lai, S. S. AU - Qiao, L. AU - Yang, R. L. AU - Xue, B. AU - Pan, F. Y. AU - Chen, H. Q. AU - Li, C. J. PY - 2011 DA - 2011// TI - GGPPS, a new EGR-1 target gene, reactivates ERK 1/2 signaling through increasing Ras prenylation JO - Am J Pathol VL - 179 UR - https://doi.org/10.1016/j.ajpath.2011.08.011 DO - 10.1016/j.ajpath.2011.08.011 ID - Shen2011 ER - TY - JOUR AU - Sahai, E. AU - Marshall, C. J. PY - 2002 DA - 2002// TI - RHO-GTPases and cancer JO - Nat Rev Cancer VL - 2 UR - https://doi.org/10.1038/nrc725 DO - 10.1038/nrc725 ID - Sahai2002 ER - TY - JOUR AU - Calvisi, D. F. AU - Ladu, S. AU - Conner, E. A. AU - Seo, D. AU - Hsieh, J. T. AU - Factor, V. M. AU - Thorgeirsson, S. S. PY - 2011 DA - 2011// TI - Inactivation of Ras GTPase-activating proteins promotes unrestrained activity of wild-type Ras in human liver cancer JO - J Hepatol VL - 54 UR - https://doi.org/10.1016/j.jhep.2010.06.036 DO - 10.1016/j.jhep.2010.06.036 ID - Calvisi2011 ER - TY - JOUR AU - Lee, T. K. AU - Poon, R. T. AU - Yuen, A. P. AU - Man, K. AU - Yang, Z. F. AU - Guan, X. Y. AU - Fan, S. T. PY - 2006 DA - 2006// TI - Rac activation is associated with hepatocellular carcinoma metastasis by up-regulation of vascular endothelial growth factor expression JO - Clin Cancer Res VL - 12 UR - https://doi.org/10.1158/1078-0432.CCR-05-2794 DO - 10.1158/1078-0432.CCR-05-2794 ID - Lee2006 ER - TY - JOUR AU - Huang, C. AU - Ding, G. AU - Gu, C. AU - Zhou, J. AU - Kuang, M. AU - Ji, Y. AU - He, Y. AU - Kondo, T. AU - Fan, J. PY - 2012 DA - 2012// TI - Decreased selenium-binding protein 1 enhances glutathione peroxidase 1 activity and downregulates HIF-1alpha to promote hepatocellular carcinoma invasiveness JO - Clin Cancer Res VL - 18 UR - https://doi.org/10.1158/1078-0432.CCR-12-0183 DO - 10.1158/1078-0432.CCR-12-0183 ID - Huang2012 ER - TY - JOUR AU - Yu, D. AU - Sun, X. AU - Qiu, Y. AU - Zhou, J. AU - Wu, Y. AU - Zhuang, L. AU - Chen, J. AU - Ding, Y. PY - 2007 DA - 2007// TI - Identification and clinical significance of mobilized endothelial progenitor cells in tumor vasculogenesis of hepatocellular carcinoma JO - Clin Cancer Res VL - 13 UR - https://doi.org/10.1158/1078-0432.CCR-06-2594 DO - 10.1158/1078-0432.CCR-06-2594 ID - Yu2007 ER - TY - JOUR AU - Idilman, R. AU - De Maria, N. AU - Colantoni, A. AU - Van Thiel, D. H. PY - 1998 DA - 1998// TI - Pathogenesis of hepatitis B and C-induced hepatocellular carcinoma JO - J Viral Hepat VL - 5 UR - https://doi.org/10.1046/j.1365-2893.1998.00116.x DO - 10.1046/j.1365-2893.1998.00116.x ID - Idilman1998 ER - TY - JOUR AU - Roberts, P. J. AU - Der, C. J. PY - 2007 DA - 2007// TI - Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer JO - Oncogene VL - 26 UR - https://doi.org/10.1038/sj.onc.1210422 DO - 10.1038/sj.onc.1210422 ID - Roberts2007 ER - TY - JOUR AU - Wang, D. AU - Dou, K. AU - Xiang, H. AU - Song, Z. AU - Zhao, Q. AU - Chen, Y. AU - Li, Y. PY - 2007 DA - 2007// TI - Involvement of RhoA in progression of human hepatocellular carcinoma JO - J Gastroenterol Hepatol VL - 22 UR - https://doi.org/10.1111/j.1440-1746.2006.04534.x DO - 10.1111/j.1440-1746.2006.04534.x ID - Wang2007 ER - TY - JOUR AU - Li, X. R. AU - Ji, F. AU - Ouyang, J. AU - Wu, W. AU - Qian, L. Y. AU - Yang, K. Y. PY - 2006 DA - 2006// TI - Overexpression of RhoA is associated with poor prognosis in hepatocellular carcinoma JO - Eur J Surg Oncol VL - 32 UR - https://doi.org/10.1016/j.ejso.2006.05.012 DO - 10.1016/j.ejso.2006.05.012 ID - Li2006 ER - TY - JOUR AU - Fromigue, O. AU - Hay, E. AU - Modrowski, D. AU - Bouvet, S. AU - Jacquel, A. AU - Auberger, P. AU - Marie, P. J. PY - 2006 DA - 2006// TI - RhoA GTPase inactivation by statins induces osteosarcoma cell apoptosis by inhibiting p42/p44-MAPKs-Bcl-2 signaling independently of BMP-2 and cell differentiation JO - Cell Death Differ VL - 13 UR - https://doi.org/10.1038/sj.cdd.4401873 DO - 10.1038/sj.cdd.4401873 ID - Fromigue2006 ER - TY - JOUR AU - Kenerson, H. L. AU - Yeh, M. M. AU - Yeung, R. S. PY - 2011 DA - 2011// TI - Tuberous sclerosis complex-1 deficiency attenuates diet-induced hepatic lipid accumulation JO - PloS One VL - 6 UR - https://doi.org/10.1371/journal.pone.0018075 DO - 10.1371/journal.pone.0018075 ID - Kenerson2011 ER - TY - JOUR AU - Menon, S. AU - Yecies, J. L. AU - Zhang, H. H. AU - Howell, J. J. AU - Nicholatos, J. AU - Harputlugil, E. AU - Bronson, R. T. AU - Kwiatkowski, D. J. AU - Manning, B. D. PY - 2012 DA - 2012// TI - Chronic activation of mTOR complex 1 is sufficient to cause hepatocellular carcinoma in mice JO - Sci Signal VL - 5 UR - https://doi.org/10.1126/scisignal.2002739 DO - 10.1126/scisignal.2002739 ID - Menon2012 ER - TY - JOUR AU - Chou, M. M. AU - Blenis, J. PY - 1996 DA - 1996// TI - The 70 kDa S6 kinase complexes with and is activated by the Rho family G proteins Cdc42 and Rac1 JO - Cell VL - 85 UR - https://doi.org/10.1016/S0092-8674(00)81257-X DO - 10.1016/S0092-8674(00)81257-X ID - Chou1996 ER - TY - STD TI - The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2407/14/248/prepub UR - http://www.biomedcentral.com/1471-2407/14/248/prepub ID - ref31 ER -